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The enzyme activity of bovine adrenocortical cytochrome P-450 producing pregnenolone from cholesterol: kinetic and electrophoretic studies on the reactivity of hydroxycholesterol intermediates.

作者信息

Duque C, Morisaki M, Ikekawa N, Shikita M

出版信息

Biochem Biophys Res Commun. 1978 May 15;82(1):179-87. doi: 10.1016/0006-291x(78)90593-4.

DOI:10.1016/0006-291x(78)90593-4
PMID:666833
Abstract
摘要

相似文献

1
The enzyme activity of bovine adrenocortical cytochrome P-450 producing pregnenolone from cholesterol: kinetic and electrophoretic studies on the reactivity of hydroxycholesterol intermediates.
Biochem Biophys Res Commun. 1978 May 15;82(1):179-87. doi: 10.1016/0006-291x(78)90593-4.
2
The role of cytochrome P-450 in the regulation of steroid biosynthesis.细胞色素P-450在甾体生物合成调控中的作用。
Adv Exp Med Biol. 1976;74:303-13. doi: 10.1007/978-1-4684-3270-1_23.
3
Kinetic studies on the mechanism of conversion of cholesterol to pregnenolone.胆固醇转化为孕烯醇酮机制的动力学研究。
Ann N Y Acad Sci. 1973;212:262-75. doi: 10.1111/j.1749-6632.1973.tb47601.x.
4
Substrate specificity of adrenocortical cytochrome P-450scc--I. Effect of structural modification of cholesterol side-chain on pregnenolone production.肾上腺皮质细胞色素P-450scc的底物特异性——I. 胆固醇侧链结构修饰对孕烯醇酮生成的影响。
J Steroid Biochem. 1980 May;13(5):545-50. doi: 10.1016/0022-4731(80)90211-3.
5
Beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol to pregnenolone. Oxidation-reduction potentials of the free, steroid-complexed, and adrenodoxin-complexed P-450.
J Biol Chem. 1981 Jan 10;256(1):343-50.
6
Biosynthesis of pregnenolone from cholesterol by mitochondrial enzymes of bovine adrenal cortex. The question of the participation of the 20(22)-olefins and 20, 22-epoxides of cholesterol.
Eur J Biochem. 1978 Nov 2;91(1):11-9. doi: 10.1111/j.1432-1033.1978.tb20931.x.
7
Enzyme-bound sterols of bovine adrenocortical cytochrome P-450scc.
Biochemistry. 1981 Feb 17;20(4):925-9. doi: 10.1021/bi00507a043.
8
The catalytic cycle of cytochrome P-450scc and intermediates in the conversion of cholesterol to pregnenolone.细胞色素P-450侧链裂解酶的催化循环以及胆固醇转化为孕烯醇酮过程中的中间体。
Eur J Biochem. 1984 May 2;140(3):583-91. doi: 10.1111/j.1432-1033.1984.tb08142.x.
9
Inhibition of bovine adrenocortical cytochrome P-450scc by 3,3'-dimethoxybenzidine.
Steroids. 1981 Jan;37(1):91-101. doi: 10.1016/0039-128x(81)90011-8.
10
Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.
J Biol Chem. 1979 Mar 25;254(6):2103-11.

引用本文的文献

1
Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols.胆固醇氢过氧化物作为胆固醇代谢细胞色素P450酶的底物以及25-羟基胆固醇和其他氧化甾醇的替代来源。
Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11138-42. doi: 10.1002/anie.201505002. Epub 2015 Jul 29.
2
Modulation of adrenal cell functions by cadmium salts: 2. Sites affected by CdCl2 during unstimulated steroid synthesis.镉盐对肾上腺细胞功能的调节作用：2. 未刺激状态下类固醇合成过程中受氯化镉影响的位点
Cell Biol Toxicol. 1994 Feb;10(1):23-33. doi: 10.1007/BF00757184.
3
Steroid enzyme defects leading to male pseudohermaphroditism.
导致男性假两性畸形的类固醇酶缺陷。
Indian J Pediatr. 1992 Jul-Aug;59(4):501-14. doi: 10.1007/BF02751568.
4
Cytochrome P450 in adrenocortical mitochondria.肾上腺皮质线粒体中的细胞色素P450
Mol Cell Biochem. 1979 Mar 5;24(1):21-43. doi: 10.1007/BF00220191.