Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
J Occup Environ Med. 2011 Aug;53(8):850-5. doi: 10.1097/JOM.0b013e31822589a9.
Bone lead is a cumulative measure of lead exposure that can also be remobilized. We examined repeated measures of bone lead over 11 years to characterize long-term changes and identify predictors of tibia and patella lead stores in an elderly male population.
Lead was measured every 3 to 5 years by k-x-ray fluorescence and mixed-effect models with random effects were used to evaluate change over time.
A total of 554 participants provided up to four bone lead measurements. Final models predicted a -1.4% annual decline (95% CI: -2.2 to -0.7) for tibia lead and piecewise linear model for patella with an initial decline of 5.1% per year (95% CI: -6.2 to -3.9) during the first 4.6 years but no significant change thereafter (-0.4% [95% CI: -2.4 to 1.7]).
These results suggest that bone lead half-life may be longer than previously reported.
骨骼中的铅是铅暴露的累积量，也可能会重新移动。我们检测了长达 11 年的骨骼铅的重复测量值，以描述长期变化，并确定老年男性人群的胫骨和髌骨铅储量的预测因素。
通过 K-x 射线荧光法每 3 至 5 年测量一次铅含量，并用具有随机效应的混合效应模型来评估随时间的变化。
共有 554 名参与者提供了多达 4 次的骨骼铅测量值。最终的模型预测胫骨铅的年下降率为-1.4%（95%CI：-2.2 至-0.7），髌骨铅的模型为分段线性模型，在前 4.6 年每年下降 5.1%（95%CI：-6.2 至-3.9），此后无明显变化（-0.4%[95%CI：-2.4 至 1.7]）。
这些结果表明，骨骼铅的半衰期可能比之前报道的要长。
