School of Public Health and Primary Care, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Am J Geriatr Psychiatry. 2011 Aug;19(8):730-42. doi: 10.1097/JGP.0b013e3181ff63be.
Recent evidence suggests that depression can result in abdominal obesity in the elderly. Few longitudinal studies are available and none has been conducted outside the United States.
To examine the relationship between depressive symptoms and abdominal obesity, data from 3,998 community-dwelling Chinese elderly men and women age 65 years and older with 4-year follow-up were analyzed. Depression was defined by a Geriatric Depression Scale score of 8 or higher. At baseline and after 4 years, overall obesity measures included body mass index, percentage of body fat, and general adiposity or body fat index (expressed by total body fat mass measured by DEXA (dual-energy x-ray absorptiometry) in kilograms divided by the square of stature in meters). Abdominal obesity measures included waist circumference, waist to hip ratio, and relative truncal fat (ratio of truncal fat mass to total fat mass measured by DEXA).
After adjustment for sociodemographics, lifestyle, and medical factors, the presence of clinically relevant depressive symptoms at baseline was associated with significant decrease in waist circumference at follow-up after adjusting for sociodemographic factors, baseline obesity, lifestyle, and medical factors (β = -1.801, t = -2.93, df = 1564, p = 0.0034), although this relationship disappeared in older age women in further age-stratified analysis.
This study shows that depressive symptoms may result in a decrease in abdominal obesity, suggesting that more research is needed to further explore this relationship. Similar studies conducted in different cultural groups may help to explain these conflicting findings.
最近的证据表明，抑郁可能导致老年人腹部肥胖。可用的纵向研究很少，而且都没有在美国以外的地区进行过。
为了研究抑郁症状与腹部肥胖之间的关系，对 3998 名年龄在 65 岁及以上、有 4 年随访的社区居住的中国老年男女进行了数据分析。抑郁的定义是老年抑郁量表评分达到 8 分或更高。在基线和 4 年后，整体肥胖指标包括体重指数、体脂百分比和总体肥胖或体脂指数（用 DEXA（双能 X 线吸收法）测量的总体脂肪质量除以身高的平方表示）。腹部肥胖指标包括腰围、腰臀比和相对躯干脂肪（用 DEXA 测量的躯干脂肪质量与总脂肪质量的比值）。
在校正社会人口统计学、生活方式和医疗因素后，基线时存在临床相关的抑郁症状与随访时腰围显著减少相关，在进一步按年龄分层分析中，这种关系在年龄较大的女性中消失。
这项研究表明，抑郁症状可能导致腹部肥胖减少，这表明需要进一步研究以探索这种关系。在不同文化群体中进行类似的研究可能有助于解释这些相互矛盾的发现。
