超重和肥胖的代谢综合征患者的身体成分与抑郁/焦虑症状。
Body composition and depressive/anxiety symptoms in overweight and obese individuals with metabolic syndrome.
机构信息
Division of Metabology, State Institute of Diabetes and Endocrinology of Rio de Janeiro, Rua Moncorvo Filho 90 - Centro, CEP 20211-340, Rio de Janeiro, RJ, Brazil.
出版信息
Diabetol Metab Syndr. 2013 Dec 23;5(1):82. doi: 10.1186/1758-5996-5-82.
BACKGROUND
Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS).
METHODS
Fifty patients, 18-50 years old, overweight or obese and with the diagnosis of MS based on the International Diabetes Federation (IDF) criteria were selected for this study. Body composition was evaluated using Dual Energy X-ray Absorptiometry (DXA). Depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS-Depression) and the Beck Depression Inventory (BDI). Anxiety symptoms were evaluated using HADS-Anxiety.
RESULTS
No correlation was found between depressive symptoms (HADS-Depression or BDI) and Body Mass Index (BMI) (r = 0.01; p = 0.94 and r = -0.12, p = 0.38; respectively), Waist Circumference (WC) (r = -0.06, p = 0.67 and r = -0.22, p = 0.12; respectively), and Waist-to-Hip Ratio (WHR) (r = -0.12, p = 0.40 and r = -0.17, p = 0.23; respectively). Additionally, no correlation was found among anxiety symptoms (HADS-Anxiety) and BMI (r = -0.15, p = 0.27), and WHR (r = -0.17, p = 0.24). In contrast, a significant correlation was found between percentage of total fat (DXA) and HADS-Depression (r = 0.34, p = 0.019) and HADS-Anxiety (r = 0.30, p = 0.039). Additionally, an inverse and strong correlation was found between lean mass (in grams) and HADS-Depression (r = -0.42, p = 0.004), HADS anxiety (r = -0.57, p < 0.0001), and BDI (r = -0.44, p = 0.026).
CONCLUSIONS
In individuals with MS, the percentage of body fat, and not central fat, BMI, WC, or WHR, was associated with an increased severity of anxiety and depressive symptoms. In contrast, total lean mass was strongly associated with fewer anxiety/depressive symptoms, suggesting that body composition might be related to psychiatric comorbidity in overweight individuals with MS.
背景
多项研究表明肥胖与儿童和成人的抑郁和焦虑症状严重程度之间存在关联，但关于这种关联仍存在一些争议点。本研究旨在探讨超重和肥胖的代谢综合征（MS）患者的身体成分与焦虑/抑郁症状严重程度之间的关系。
方法
选择了 50 名年龄在 18-50 岁之间的患者，他们超重或肥胖，并根据国际糖尿病联合会（IDF）标准被诊断为 MS。使用双能 X 射线吸收仪（DXA）评估身体成分。使用医院焦虑和抑郁量表（HADS-Depression）和贝克抑郁量表（BDI）评估抑郁症状。使用 HADS-Anxiety 评估焦虑症状。
结果
抑郁症状（HADS-Depression 或 BDI）与体重指数（BMI）（r=0.01;p=0.94 和 r=-0.12;p=0.38；分别）、腰围（WC）（r=-0.06;p=0.67 和 r=-0.22;p=0.12；分别）和腰臀比（WHR）（r=-0.12;p=0.40 和 r=-0.17;p=0.23；分别）之间均无相关性。此外，焦虑症状（HADS-Anxiety）与 BMI（r=-0.15;p=0.27）和 WHR（r=-0.17;p=0.24）之间也无相关性。相反，总脂肪百分比（DXA）与 HADS-Depression（r=0.34;p=0.019）和 HADS-Anxiety（r=0.30;p=0.039）之间存在显著相关性。此外，瘦体重（克）与 HADS-Depression（r=-0.42;p=0.004）、HADS 焦虑（r=-0.57;p<0.0001）和 BDI（r=-0.44;p=0.026）之间呈负相关且相关性较强。
结论
在 MS 患者中，体脂肪百分比而不是中心性脂肪、BMI、WC 或 WHR 与焦虑和抑郁症状严重程度增加相关。相反，总瘦体重与较少的焦虑/抑郁症状强烈相关，这表明身体成分可能与超重的 MS 患者的精神共病有关。
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