Liu Ying, Qi Hao, Sun Run-guang, Chen Wen-fang
Biophysics Laboratory, College of Physics and Information Technology, Shaanxi Normal University, Xiían, China.
Tumori. 2011 May-Jun;97(3):386-92. doi: 10.1177/030089161109700322.
Cell membranes were shown to be sensitive to and affected by static magnetic fields (SMF).
Cells were treated with four anticancer drugs followed by treatment with a combination of drugs and SMF. Individual cells were examined using atomic force microscopy (AFM). The drugs were taxol (alkaloid), doxorubicin (anthracycline), cisplatin (platinum compound) and cyclophosphamide (alkylating agent).
Holes were observed in cells exposed to SMF but not in control groups. The number, size and shape of the holes were dependent on the drug type, SMF parameters and the duration of exposure.
The results suggest that the application of a SMF could alter membrane permeability, increasing the flow of the anticancer drugs. This may be one of the reasons why SMF can strengthen the effect of anticancer drugs. Observations were also made of the effect of using different anticancer drugs. For example, the effect of SMF combined with taxol or cyclophosphamide on the cells was additive while the effect of SMF combined with cisplatin or doxorubicin was synergistic. The target sites of cisplatin and doxorubicin are nucleic acids; continued research is required into this important area to ascertain the effect of SMF on nucleic acids.
细胞膜已被证明对静磁场（SMF）敏感并受其影响。
细胞先用四种抗癌药物处理，然后用药物与静磁场联合处理。使用原子力显微镜（AFM）对单个细胞进行检测。这些药物分别是紫杉醇（生物碱）、阿霉素（蒽环类）、顺铂（铂化合物）和环磷酰胺（烷化剂）。
在暴露于静磁场的细胞中观察到有孔，而对照组中未观察到。孔的数量、大小和形状取决于药物类型、静磁场参数和暴露持续时间。
结果表明，施加静磁场可改变膜通透性，增加抗癌药物的流量。这可能是静磁场能增强抗癌药物效果的原因之一。还观察了使用不同抗癌药物的效果。例如，静磁场与紫杉醇或环磷酰胺联合对细胞的作用是相加的，而静磁场与顺铂或阿霉素联合的作用是协同的。顺铂和阿霉素的作用靶点是核酸；需要在这一重要领域继续开展研究以确定静磁场对核酸的影响。
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