McDonald W J, Golper T A, Mass R D, Kendall J W, Porter G A, Girard D E, Fischer M D
J Clin Endocrinol Metab. 1979 Jan;48(1):92-5. doi: 10.1210/jcem-48-1-92.
The ACTH-cortisol axis was studied in 15 hemodialysis patients. Basal plasma cortisol concentrations were found to be elevated and ACTH to be in the high normal range. Cortisol responded normally to exogenous ACTH, but neither cortisol nor ACTH were suppressed in response to oral dexamethasone. 11-Deoxycortisol and ACTH concentrations did not rise normally in response to either oral or iv metyrapone. We conclude that standard testing of the ACTH-cortisol axis in dialysis patients yields results suggesting Cushing's syndrome.
对15名血液透析患者的促肾上腺皮质激素-皮质醇轴进行了研究。发现基础血浆皮质醇浓度升高，促肾上腺皮质激素处于高正常范围。皮质醇对外源性促肾上腺皮质激素反应正常，但口服地塞米松后，皮质醇和促肾上腺皮质激素均未被抑制。口服或静脉注射甲吡酮后，11-脱氧皮质醇和促肾上腺皮质激素浓度均未正常升高。我们得出结论，对透析患者的促肾上腺皮质激素-皮质醇轴进行标准检测，结果提示库欣综合征。
