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Impact of age on the efficacy of newer adjuvant therapies in patients with stage II/III colon cancer: findings from the ACCENT database.年龄对 II/III 期结肠癌患者新型辅助治疗疗效的影响:ACCENT 数据库的研究结果。
J Clin Oncol. 2013 Jul 10;31(20):2600-6. doi: 10.1200/JCO.2013.49.6638. Epub 2013 Jun 3.
2
Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study.不可切除的转移性结直肠癌患者能否停用化疗?GERCOR OPTIMOX2研究。
J Clin Oncol. 2009 Dec 1;27(34):5727-33. doi: 10.1200/JCO.2009.23.4344. Epub 2009 Sep 28.
3
Clinical trial enrollment, patient characteristics, and survival differences in prospectively registered metastatic colorectal cancer patients.前瞻性登记的转移性结直肠癌患者的临床试验入组情况、患者特征及生存差异
Cancer. 2009 Oct 15;115(20):4679-87. doi: 10.1002/cncr.24527.
4
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial.在MOSAIC试验中,奥沙利铂、氟尿嘧啶和亚叶酸作为II期或III期结肠癌辅助治疗可提高总生存率。
J Clin Oncol. 2009 Jul 1;27(19):3109-16. doi: 10.1200/JCO.2008.20.6771. Epub 2009 May 18.
5
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.西妥昔单抗与化疗联合作为转移性结直肠癌的初始治疗方案
N Engl J Med. 2009 Apr 2;360(14):1408-17. doi: 10.1056/NEJMoa0805019.
6
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.汇集安全性和疗效分析,使用转移性结直肠癌患者的个体数据,检验体能状态对9项一线治疗试验结果的影响。
J Clin Oncol. 2009 Apr 20;27(12):1948-55. doi: 10.1200/JCO.2008.20.2879. Epub 2009 Mar 2.
7
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.转移性结直肠癌的化疗、贝伐单抗和西妥昔单抗
N Engl J Med. 2009 Feb 5;360(6):563-72. doi: 10.1056/NEJMoa0808268.
8
Toxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience.MRC COIN试验中与奥沙利铂联合氟嘧啶(无论有无西妥昔单抗)相关的毒性反应经验。
Br J Cancer. 2009 Jan 27;100(2):251-8. doi: 10.1038/sj.bjc.6604877.
9
Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel.手术与化疗联合以及靶向药物在结直肠癌肝转移患者治疗中的作用:专家小组建议
Ann Oncol. 2009 Jun;20(6):985-92. doi: 10.1093/annonc/mdn735. Epub 2009 Jan 19.
10
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer.一项随机 IIIB 期试验:比较化疗、贝伐单抗和帕尼单抗联合治疗与单纯化疗和贝伐单抗治疗转移性结直肠癌的疗效。
J Clin Oncol. 2009 Feb 10;27(5):672-80. doi: 10.1200/JCO.2008.19.8135. Epub 2008 Dec 29.

平衡结直肠癌化疗的疗效和毒性。

Balancing the efficacy and toxicity of chemotherapy in colorectal cancer.

机构信息

Consultant, Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK.

出版信息

Ther Adv Med Oncol. 2011 Jan;3(1):43-52. doi: 10.1177/1758834010388342.

DOI:10.1177/1758834010388342
PMID:21789155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3126034/
Abstract

As the therapeutic options for the treatment of colorectal cancer have expanded over the past 20 years, so has the complexity of decision making. The goals of treatment in the palliative, adjuvant and neoadjuvant settings vary and it is not only the efficacy of drugs that influence treatment decisions. Age, performance status, the presence of significant comorbidities and the different treatment regimens and strategies provide medical oncologists with an array of options to attempt to maximize patients' quality of life and longevity.

摘要

随着过去 20 年来治疗结直肠癌的治疗选择的不断扩展,决策的复杂性也在增加。姑息治疗、辅助治疗和新辅助治疗的目标不同,影响治疗决策的不仅是药物的疗效。年龄、体能状态、是否存在严重合并症以及不同的治疗方案和策略为肿瘤内科医生提供了一系列的选择,以尽量提高患者的生活质量和延长寿命。