Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Prenat Diagn. 2011 Nov;31(11):1066-9. doi: 10.1002/pd.2834. Epub 2011 Jul 24.
To compare the outcomes after mid-pregnancy cordocentesis between singleton and twin pregnancies.
We compared immediate complications and pregnancy outcomes between a cohort of twin pregnancies undergoing mid-pregnancy diagnostic cordocentesis between the years 1989 and 2010, and a control group of singleton pregnancies matched based on maternal age and years of the procedure with a ratio of 1:3.
Among 6147 pregnancies undergoing cordocentesis during the study period, 122 twin fetuses met the study criteria and were matched with 336 singleton controls. Success rate of sampling was slightly higher in singleton than in twin gestations (98.8% vs 97.3%), and time required for the procedure was significantly longer in the twin group (8.1 vs 6.3 min, p = 0.02). Immediate complications, such as fetal bradycardia and transient bleeding from the puncture site, were significantly higher in twins (13% vs 6.0%, p = 0.001; and 34.8% vs 26.1%, p = 0.03, respectively). However, fetal loss rate within 2 weeks of cordocentesis was not different (1.4% and 1.1%, p = 0.42).
Immediate complications following cordocentesis are significantly higher in twin pregnancies, but fetal loss rate within 2 weeks of the procedure is comparable.
比较单胎妊娠和双胎妊娠在妊娠中期脐带穿刺后的结局。
我们比较了 1989 年至 2010 年间进行妊娠中期诊断性脐带穿刺的一组双胎妊娠的即刻并发症和妊娠结局，并与根据母亲年龄和手术年份按 1:3 的比例匹配的一组单胎妊娠对照组进行比较。
在研究期间进行脐带穿刺的 6147 例妊娠中，122 例双胎胎儿符合研究标准，并与 336 例单胎对照匹配。单胎妊娠的取样成功率略高于双胎妊娠（98.8% vs 97.3%），双胎妊娠组的手术时间明显延长（8.1 分钟 vs 6.3 分钟，p=0.02）。即刻并发症，如胎儿心动过缓和穿刺部位短暂出血，在双胎妊娠中明显更高（13% vs 6.0%，p=0.001；34.8% vs 26.1%，p=0.03）。然而，脐带穿刺后 2 周内的胎儿丢失率无差异（1.4%和 1.1%，p=0.42）。
双胎妊娠脐带穿刺后即刻并发症明显较高，但术后 2 周内的胎儿丢失率无差异。
