Ehlayel M S, Bener A, Sabbah A
Section of Pediatric Allergy-Immunology, Department of Pediatrics, Hamad Medical Corporation, Doha, State of Qatar.
Eur Ann Allergy Clin Immunol. 2011 Jun;43(3):81-8.
Studies suggest a link between vitamin D deficiency and development of asthma and allergic diseases.
To determine a) the association between vitamin D and asthma among children, b) difference in level of vitamin D in asthmatic children and control, and c) effect of vitamin D on atopy markers.
Case-control study done, between October 2009 to July 2010, on asthmatics and controls (< 15 years) at Pediatric Allergy-Immunology Clinics and Primary Health care Clinics (PHC), Qatar. METHODS & SUBJECTS: A total of 483 cases and 483 controls matched by age, gender and ethnicity. Sociodemographic & clinical data was collected through physician diagnosis and questionnaire. Their health status was assessed by past or present clinical manifestations, family history, physical examination, BMI, and serum 25(OH) vitamin D, calcium, and phosphorus.
44.8% of asthmatic and 50.0% of controls were males, and 55.2% of asthmatic and 50% of controls were females. The mean age (+/- SD, in years)for asthmatic versus controls was 7.0 +/- 3.8 vs. 8.4 +/- 3.6. Vitamin D deficiency was more prevalent in asthmatics than controls. The mean value of Vitamin D in asthmatics was much lower than the normal value, and there was a significant difference found in the mean values of vitamin D between asthmatics (17.5 +/- 11.0) and the controls (20.8 +/- 10.0). Furthermore, there were statistically significant differences between asthmatic subjects and controls with respect to serum level of vitamin D (p < 0.001). Lower Vitamin D levels were associated with more allergic disease and elevated serum IgE.
Serum vitamin D levels were lower in asthmatic than control. Vitamin D deficiency was higher among children with asthma, allergic rhinitis, atopic dermatitis, acute urticaria, and food allergy. In addition, vitamin D deficiency was associated with IgE atopy markers in asthmatic children more than controls.
研究表明维生素D缺乏与哮喘及过敏性疾病的发生之间存在联系。
确定a）儿童中维生素D与哮喘之间的关联，b）哮喘儿童与对照组维生素D水平的差异，以及c）维生素D对特应性标志物的影响。
2009年10月至2010年7月在卡塔尔的儿科过敏免疫诊所和初级卫生保健诊所（PHC）对哮喘患者和对照组（<15岁）进行的病例对照研究。
共483例病例和483例对照，按年龄、性别和种族匹配。通过医生诊断和问卷收集社会人口统计学和临床数据。通过过去或现在的临床表现、家族史、体格检查、BMI以及血清25（OH）维生素D、钙和磷评估他们的健康状况。
44.8%的哮喘患者和50.0%的对照组为男性，55.2%的哮喘患者和50%的对照组为女性。哮喘患者与对照组的平均年龄（±标准差，岁）分别为7.0±3.8和8.4±3.6。哮喘患者中维生素D缺乏比对照组更普遍。哮喘患者中维生素D的平均值远低于正常值，哮喘患者（17.5±11.0）和对照组（20.8±10.0）之间维生素D的平均值存在显著差异。此外，哮喘患者和对照组在血清维生素D水平方面存在统计学显著差异（p<0.001）。较低的维生素D水平与更多的过敏性疾病和血清IgE升高有关。
哮喘患者的血清维生素D水平低于对照组。哮喘、过敏性鼻炎、特应性皮炎、急性荨麻疹和食物过敏儿童中维生素D缺乏更高。此外，与对照组相比，哮喘儿童中维生素D缺乏与IgE特应性标志物的关联更强。
