Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.
Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.
J Mol Neurosci. 2019 Mar;67(3):373-387. doi: 10.1007/s12031-018-1237-5. Epub 2019 Jan 3.
Vitamin or mineral supplementation is considered to be the most commonly used medical treatment for autism spectrum disorder (ASD), in addition to other interventions such as neurological and psychological interventions. There is not much evidence of therapeutic efficacy between vitamin and mineral supplementation and improvements in ASD. However, several researchers have noted that patients with ASD have various metabolic and nutritional abnormalities including issues with sulfation, methylation, glutathione redox imbalances, oxidative stress, and mitochondrial dysfunction. There is some evidence that vitamin and mineral supplementation may support these basic physiologic processes. Recently, the nutritional status of ASD patients has been gaining focus in this particular area. Pointing out the nutritional status as a potential etiological factor for attention/communication disorders, more importance has been given to this particular point. Moreover, autistic specific considerations like the feature and behavior of ASD might be increased or at least fall in the higher risk due to the sub-optimal nutritional status.
维生素或矿物质补充剂被认为是自闭症谱系障碍 (ASD) 的最常用医学治疗方法，除了其他干预措施，如神经和心理干预。维生素和矿物质补充剂与 ASD 改善之间的治疗效果证据并不多。然而，一些研究人员指出，ASD 患者存在多种代谢和营养异常，包括硫酸盐、甲基化、谷胱甘肽氧化还原失衡、氧化应激和线粒体功能障碍。有一些证据表明，维生素和矿物质补充剂可能支持这些基本生理过程。最近，ASD 患者的营养状况在这一特定领域受到关注。指出营养状况是注意力/沟通障碍的一个潜在病因因素，这一点变得更加重要。此外，由于营养状况不佳，自闭症特有的考虑因素，如 ASD 的特征和行为，可能会增加，或者至少处于更高的风险之中。
