Dumas O, Roget L, Coppéré H, David A, Richard P, Barthélémy C, Veyret C, Audigier J C
Service de Gastroentérologie et d'Hépatologie, CHRU de Saint-Etienne, Hôpital Nord, Saint-Priest-en-Jarez.
Gastroenterol Clin Biol. 1990;14(1):67-73.
This study was carried out in order to compare the accuracy of ultrasound and ultrasonically guided fine-needle aspiration biopsy in screening for tumoral hepatic syndrome in 206 patients. According to their different clinical presentations, patients were divided into 4 groups: 1: Documented cancer, 2: Hepatic cirrhosis, 3: Fortuitous ultrasonic detection, 4: Clinical hepatic tumor. Cytologic findings were divided into 4 types: benign, primary malignant tumor, secondary malignant tumor (with or without etiologic orientation) non significant result. The ultrasonic and cytologic results were retrospectively compared to definitive diagnosis which was known in 199 patients. No early or delayed complications related to fine-needle aspiration biopsy were recorded. Ultrasonic imaging globally suggested the final diagnosis in 116 patients (diagnostic precision: 58.2 percent) while the cytologic result corresponded to final diagnosis in 183 patients (diagnostic precision: 92.5 percent). Improved results by fine-needle aspiration biopsy with regard to ultrasound was recorded in each group, particularly in group 3; its diagnostic sensitivity was 92 percent for malignant lesions with 100 percent specificity and an excellent value in discriminating between their primitive or secondary nature. Fine-needle aspiration biopsy gave an exact etiologic orientation in half of cases with metastasis and helped to discover the primitive tumor in some patients when this was not known previously. We conclude that fine-needle aspiration biopsy is a simple, moderately invasive and accurate procedure in the diagnosis of hepatic lesions. As ultrasound alone is not suggestive, especially in the case of a fortuitous ultrasonic detection, fine-needle aspiration biopsy improves diagnostic precision.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在比较超声及超声引导下细针穿刺活检对206例患者肝肿瘤综合征筛查的准确性。根据不同临床表现,患者被分为4组:1:确诊癌症;2:肝硬化;3:偶然超声发现;4:临床肝肿瘤。细胞学检查结果分为4种类型:良性、原发性恶性肿瘤、继发性恶性肿瘤(有或无病因指向)、无显著结果。将超声和细胞学检查结果与199例已知的确诊诊断进行回顾性比较。未记录与细针穿刺活检相关的早期或延迟并发症。超声成像总体上对116例患者提示了最终诊断(诊断准确率:58.2%),而细胞学检查结果与183例患者的最终诊断相符(诊断准确率:92.5%)。每组中细针穿刺活检相对于超声的结果均有改善,尤其是在第3组;其对恶性病变的诊断敏感性为92%,特异性为100%,在区分其原发性或继发性性质方面具有优异价值。细针穿刺活检在一半的转移病例中给出了确切的病因指向,并有助于在一些先前未知的患者中发现原发性肿瘤。我们得出结论,细针穿刺活检是一种简单、微创且准确的肝病变诊断方法。由于单独超声检查不具有提示性,尤其是在偶然超声发现的情况下,细针穿刺活检提高了诊断准确性。(摘要截选至250字)