Liao Shichong, Li Jinxin, Wei Wen, Wang Lijun, Zhang Yimin, Li Juanjuan, Wang Changhua, Sun Shenrong
Department of Thyroid and Breast Surgery, Renmin Hospital, Wuhan, China.
Asian Pac J Cancer Prev. 2011;12(4):1061-5.
AIM/HYPOTHESIS: Diabetes and breast cancer are both serious life-threatening diseases across the world. Some studies shows that diabetes is associated with many kinds of tumor, but links with breast cancer remain controversial. The aim of this study was to assess the association the available evidence.
A meta-analysis was conducted including 16 studies published between 2000 and 2010 and summary relative risks(RRs) with 95% CIs were calculated using random-effects model.
The combined evidence supports that diabetes was associated with a statistically significant 23% increased risk of breast cancer, especially in postmenopausal women (RR=1.25 95%CI 1.20-1.29). The correlation between diabetes and breast cancer was the most obvious in Europe (RR=1.88,95%CI:1.56-2.25), followed by America (RR=1.16, 95%CI:1.12-1.20). In Asia the result was not significant (RR=1.01, 95%CI=0.84-1.21). Diabetes also increased mortality from breast cancer overall (RR=1.44, 95%CI:1.31-1.58).
CONCLUSIONS/INTERPRETATION: This meta-analysis indicated that diabetes can be considered as a risk factor for breast cancer. In addition, menstruation status as well as geographical distribution can affect the relationship.
目的/假设：糖尿病和乳腺癌在全球都是严重威胁生命的疾病。一些研究表明糖尿病与多种肿瘤相关，但与乳腺癌的关联仍存在争议。本研究的目的是评估现有证据之间的关联。
进行了一项荟萃分析，纳入了2000年至2010年间发表的16项研究，并使用随机效应模型计算了汇总相对风险（RR）及95%置信区间（CI）。
综合证据支持糖尿病与乳腺癌风险在统计学上显著增加23%相关，尤其是在绝经后女性中（RR = 1.25，95%CI 1.20 - 1.29）。糖尿病与乳腺癌之间的相关性在欧洲最为明显（RR = 1.88，95%CI：1.56 - 2.25），其次是美国（RR = 1.16，95%CI：1.12 - 1.20）。在亚洲，结果不显著（RR = 1.01，95%CI = 0.84 - 1.21）。糖尿病总体上也增加了乳腺癌的死亡率（RR = 1.44，95%CI：1.31 - 1.58）。
结论/解读：这项荟萃分析表明糖尿病可被视为乳腺癌的一个风险因素。此外，月经状态以及地理分布会影响这种关系。
