Fernández-Arce Lucía, Robles-Rodríguez Nena, Fernández-Feito Ana, Fernández-Iglesias Rocío, Fernández-Álvarez María Del Mar, Lana Alberto
Department of Medicine, Faculty of Medicine and Health Sciences, University of Oviedo/ISPA, 33006 Oviedo, Spain.
Department of Surgery and Medical Surgical Specialities, Faculty of Medicine and Health Sciences, University of Oviedo/ISPA, 33006 Oviedo, Spain.
Cancers (Basel). 2024 Aug 15;16(16):2853. doi: 10.3390/cancers16162853.
During breast cancer (BC), cardiometabolic disorders can worsen prognosis, particularly in women with type 2 diabetes mellitus (T2DM). This study aimed to determine the impact of BC diagnosis on cardiometabolic parameters and the incidence of complication in women over 50 years of age (90% aged ≥ 65 years) with pre-existing T2DM. Using primary care registries from Asturias (Spain), a total of 106 women diagnosed with T2DM followed by BC were selected and matched with women with T2DM ( = 212) in a cohort study. Indicators of cardiometabolic health and microvascular complications associated with T2DM were collected. Women were monitored from two years prior to five years after BC diagnosis. Conditional logistic regressions were used to compare the adjusted odds of staying below each indicator's threshold. During follow-up, women with T2DM+BC had a higher risk of fasting blood glucose ≥126 mg/dL (adjusted odds ratio [aOR] = 1.83; 95% confidence interval [CI95%]: 1.01-3.32) and glycosylated hemoglobin (Hb1Ac) ≥ 48 mmol/mol or 6.5% (aOR: 2.44; IC95%: 1.21-4.91). There was no difference between the groups regarding the incidence of microvascular complications. BC incidence negatively impacted the glycemic control of Spanish women with pre-existing T2DM measured by basal blood glucose and HbA1c, but not cardiometabolic health indicators or T2DM complications.
在乳腺癌（BC）期间，心脏代谢紊乱会使预后恶化，尤其是在2型糖尿病（T2DM）女性中。本研究旨在确定BC诊断对50岁以上（90%年龄≥65岁）患有T2DM的女性心脏代谢参数和并发症发生率的影响。利用来自西班牙阿斯图里亚斯的初级保健登记处，在一项队列研究中，共选择了106例诊断为T2DM后又患BC的女性，并与患有T2DM的女性（n = 212）进行匹配。收集了与T2DM相关的心脏代谢健康指标和微血管并发症。在BC诊断前两年至诊断后五年对女性进行监测。使用条件逻辑回归比较保持在每个指标阈值以下的调整后几率。在随访期间，患有T2DM + BC的女性空腹血糖≥126 mg/dL的风险更高（调整后优势比[aOR] = 1.83；95%置信区间[CI95%]：1.01 - 3.32），糖化血红蛋白（Hb1Ac）≥48 mmol/mol或6.5%的风险更高（aOR：2.44；IC95%：1.21 - 4.91）。两组在微血管并发症发生率方面没有差异。BC的发生对西班牙患有T2DM的女性的血糖控制产生了负面影响，这通过基础血糖和糖化血红蛋白来衡量，但对心脏代谢健康指标或T2DM并发症没有影响。
