Melamed Michal L, Manson JoAnn E
Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Womens Health (Lond). 2011 Jul;7(4):419-24. doi: 10.2217/whe.11.18.
Low vitamin D levels are more common in women than in men. Low vitamin D levels have been implicated in numerous disease processes including fracture risk, falls, cardiovascular disease, hypertension, diabetes mellitus and cancers. In this article we review recent evidence regarding associations between low vitamin D levels and cancers and cardiovascular disease. We also review evidence regarding associations between high vitamin D levels and vascular calcifications and pancreatic cancer. It appears that there is probably an optimal level of vitamin D that is neither too high nor too low that is required to maximize health. On going clinical trials should aid in elucidating the optimal levels of 25-hydroxyvitamin D for numerous health outcomes.
维生素D水平低在女性中比在男性中更常见。低维生素D水平与许多疾病过程有关，包括骨折风险、跌倒、心血管疾病、高血压、糖尿病和癌症。在本文中，我们回顾了关于低维生素D水平与癌症和心血管疾病之间关联的最新证据。我们还回顾了关于高维生素D水平与血管钙化和胰腺癌之间关联的证据。似乎可能存在一个既不太高也不太低的最佳维生素D水平，以实现健康最大化。正在进行的临床试验应有助于阐明多种健康结局所需的25-羟基维生素D的最佳水平。
