1 Scott & White Digestive Disease Research Center, 2 Division of Research, Central Texas Veterans Health Care System, 3 Department of Internal Medicine, Division of Gastroenterology, Scott & White Healthcare and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA.
Ann Transl Med. 2014 Jan;2(1):9. doi: 10.3978/j.issn.2305-5839.2013.03.04.
proliferation, differentiation and apoptosis. It is now commonly recognized that low levels of vitamin D are associated with a greater risk of tumorigenesis. Cancers of the gastrointestinal tract are most often difficult to diagnose and treat as patients typically present with progressed disease. Basic research, clinical trials and population studies have supported the concept that treatment with Vitamin D may be a therapeutic option when treating GI cancers, however treatments must be individualized and monitored closely as the side effects from Vitamin D treatment can be increasingly harmful. This review will highlight the most recent findings regarding Vitamin D signaling and GI cancers.
维生素 D 的合成和信号转导影响许多细胞过程，包括增殖、分化和凋亡。现在人们普遍认识到，维生素 D 水平低与肿瘤发生的风险增加有关。胃肠道癌症通常很难诊断和治疗，因为患者通常表现出进展期疾病。基础研究、临床试验和人群研究支持这样一种观点，即维生素 D 治疗可能是治疗胃肠道癌症的一种治疗选择，然而，治疗必须个体化，并密切监测，因为维生素 D 治疗的副作用可能会越来越有害。这篇综述将重点介绍关于维生素 D 信号转导和胃肠道癌症的最新发现。
