Department of Pharmacology, M.G.V's Pharmacy College, Panchavati, Nasik 422003, Maharashtra, India.
Nat Prod Res. 2012;26(6):570-4. doi: 10.1080/14786419.2010.534473. Epub 2011 Jul 27.
Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis (Malvaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, uric acid and insulin in fructose-induced hypertension model. A-HRS treatment (100 and 300 mg kg⁻¹, p.o. for 6 weeks) reduced SBP, vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose (10%) treatment for 6 weeks. The cumulative concentration response curve (CCRC) of angiotensin II (Ang II) was shifted towards the right in rats treated with A-HRS using an isolated strip of ascending colon. The results suggest that A-HRS could prevent the development of high-blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, A-HRS has an antihypertensive action in a fructose model.
果糖喂养会导致正常大鼠血压升高，这与胰岛素抵抗、高胰岛素血症、高血糖、高胆固醇血症和高三酰甘油血症有关。我们研究了从木槿（锦葵科）中分离得到的 A-HRS（100 和 300mg/kg；口服）对果糖诱导的高血压模型中收缩压（SBP）、血管反应性、血清葡萄糖、甘油三酯、胆固醇、尿酸和胰岛素的影响。A-HRS 治疗（100 和 300mg/kg，口服 6 周）可降低 SBP，改变儿茶酚胺引起的血管反应性，并逆转果糖（10%）治疗 6 周引起的代谢变化。用分离的升结肠段对用 A-HRS 处理的大鼠进行血管紧张素 II（Ang II）的累积浓度反应曲线（CCRC）显示右移。结果表明，A-HRS 可能通过逆转果糖引起的代谢变化来预防富含果糖的饮食引起的高血压的发展。总之，A-HRS 在果糖模型中具有降压作用。
