Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nasik, Maharashtra, India.
J Ethnopharmacol. 2009 Oct 29;126(1):86-9. doi: 10.1016/j.jep.2009.08.008. Epub 2009 Aug 13.
Solanum torvum (Solanaceae) is a plant used in Cameroon ethnomedicine for the treatment of hypertension.
The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, insulin and uric acid in fructose-induced hypertension.
The effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on fructose (10%) induced rise in blood pressure was tested by invasive and non-invasive measurements and the biochemical parameters were studied by using standard kits.
Ethanolic extract of Solanum torvum reduced systolic blood pressure, vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration response curve (CCRC) of Angiotensin II (Ang II) using isolated strip of ascending colon was shifted towards right in rats treated with ethanolic extract of Solanum torvum.
In conclusion, ethanolic extract of Solanum torvum could prevent the development of high blood pressure induced by a diet rich in fructose probably by reversing the metabolic alterations induced by fructose.
龙葵（茄科）是一种在喀麦隆传统医学中用于治疗高血压的植物。
本研究旨在确定龙葵乙醇提取物（100 和 300mg/kg；口服，6 周）对果糖诱导高血压的收缩压（SBP）、血管反应性、血清葡萄糖、甘油三酯、胆固醇、胰岛素和尿酸的影响。
通过侵入性和非侵入性测量测试龙葵乙醇提取物（100 和 300mg/kg；口服，6 周）对果糖（10%）引起的血压升高的影响，并使用标准试剂盒研究生化参数。
龙葵乙醇提取物降低了收缩压、儿茶酚胺引起的血管反应性变化，并逆转了果糖引起的代谢改变。用分离的升结肠条对龙葵乙醇提取物处理的大鼠进行血管紧张素 II（Ang II）的累积浓度反应曲线（CCRC）显示向右侧移位。
总之，龙葵乙醇提取物可能通过逆转果糖引起的代谢改变来预防富含果糖的饮食引起的高血压的发展。
