Meunier P J
Faculté Médecin des Hôpitaux, Hôpital Edouard Herriot, Lyon/Frankreich.
Fortschr Med. 1990 Jan 15;108(1):45-8.
The ideal curative treatment of osteoporosis must be capable of raising the trabecular bone mass to its former level, since only a substantial increase in bone mass can reduce the fracture rate of the spine. Fluoride is an effective activator of osteoblasts and thus increases axial bone mass and decreases the vertebral fracture rate. The drawbacks of the formerly used sodium fluoride such as gastrolesivity and its in compatibility with concomitant calcium intake were overcome by using sodium monofluorophosphate (MFP) as the source of fluoride. MFP is well tolerated gastrointestinally and can be used concomitantly with calcium-containing medicaments or with calcium-rich alimentation. Fluoride treatment has proved to be an effective measure against continued progression of osteoporosis, and possible risks present no difficulties. The benefits of this therapy certainly outweigh possible adverse effects.
理想的骨质疏松症治疗方法必须能够将小梁骨量提高到以前的水平，因为只有骨量的大幅增加才能降低脊柱骨折率。氟化物是成骨细胞的有效激活剂，因此可增加轴向骨量并降低椎体骨折率。通过使用单氟磷酸钠（MFP）作为氟化物来源，克服了以前使用的氟化钠的缺点，如胃肠道刺激性及其与同时摄入钙的不相容性。MFP在胃肠道耐受性良好，可与含钙药物或富含钙的营养物质同时使用。氟化物治疗已被证明是对抗骨质疏松症持续进展的有效措施，并且可能存在的风险也不难解决。这种疗法的益处肯定超过可能的不良反应。
