Pathology Department, Beaujon Hospital, Clichy, France.
Pathol Int. 2011 Aug;61(8):491-4. doi: 10.1111/j.1440-1827.2011.02691.x. Epub 2011 Jul 21.
Serum alpha-fetoprotein (AFP), the main serum marker of hepatocellular carcinoma, may increase in some benign conditions involving the liver but is usually within normal values in focal nodular hyperplasia (FNH) in adults. We present a case of a FNH associated with serum AFP increase, and in which both the lesion and the non-lesional adjacent liver showed AFP-positive immunostained areas. Moreover, only one case of FNH with AFP-positive immunostaining has been previously reported. In addition, our case of FNH is remarkable as it displayed some morphological and immunophenotypical features of progenitor cells. The serum AFP levels rose after liver resection and progressively returned to the preoperative high values. These findings are concordant with the hypothesis that FNH is a regenerative process, and suggest that regenerative areas in the liver might be the source of AFP production.
血清甲胎蛋白（AFP）是肝细胞癌的主要血清标志物，在一些涉及肝脏的良性疾病中可能会升高，但在成人局灶性结节性增生（FNH）中通常在正常值范围内。我们报告了一例与血清 AFP 升高相关的 FNH，病变和非病变相邻肝组织均显示 AFP 阳性免疫染色区。此外，之前仅报道过一例 FNH 伴有 AFP 阳性免疫染色。此外，我们的 FNH 病例值得注意，因为它显示了祖细胞的一些形态和免疫表型特征。肝切除术后血清 AFP 水平升高，并逐渐恢复到术前的高值。这些发现与 FNH 是一种再生过程的假说一致，并提示肝脏的再生区可能是 AFP 产生的来源。
