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大鼠与人类肝细胞增殖性病变的比较组织形态学综述

Comparative histomorphological review of rat and human hepatocellular proliferative lesions.

作者信息

Thoolen Bob, Ten Kate Fiebo J W, van Diest Paul J, Malarkey David E, Elmore Susan A, Maronpot Robert R

机构信息

Global Pathology Support, Benoordenhoutseweg 23, 2596 BA The Hague, The Netherlands ; University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

出版信息

J Toxicol Pathol. 2012 Sep;25(3):189-99. doi: 10.1293/tox.25.189. Epub 2012 Oct 1.

DOI:10.1293/tox.25.189
PMID:22988337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3434334/
Abstract

In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

摘要

在本比较性综述中，使用苏木精和伊红染色切片检查大鼠和人类常见的非肿瘤性和肿瘤性肝细胞病变的组织形态学特征。呈现并讨论了肿瘤性病变（肝细胞癌和肝细胞腺瘤）和推定的癌前病变（人类的大细胞和小细胞改变以及大鼠的细胞改变灶）的形态学异同。大鼠和人类肝细胞增殖性病变的诊断特征、生长模式和行为以及肝癌发生过程存在主要相似之处。对人类和大鼠推定的癌前病变的进一步研究应有助于进一步明确它们在这两个物种向肝细胞肿瘤进展中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/dfbcc1941928/tox-25-189-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/2e018dd9d599/tox-25-189-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/8cd12b1ace95/tox-25-189-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/dfbcc1941928/tox-25-189-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/806d20ffd855/tox-25-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/331cdc9409ec/tox-25-189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/da6f224c0941/tox-25-189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/79044510072a/tox-25-189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/67d1d60157ab/tox-25-189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/dcf4894acd38/tox-25-189-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/3c419519308c/tox-25-189-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/71a3c032f461/tox-25-189-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/2e018dd9d599/tox-25-189-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de2/3434334/f1f0f49eb308/tox-25-189-g010.jpg
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