细菌对质膜处宿主肌动蛋白动力学的颠覆作用。
Bacterial subversion of host actin dynamics at the plasma membrane.
机构信息
Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK.
出版信息
Cell Microbiol. 2011 Oct;13(10):1460-9. doi: 10.1111/j.1462-5822.2011.01651.x. Epub 2011 Aug 31.
Abstract
Invasion of non-phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin-rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin-rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts - actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.
摘要
许多细菌病原体通过非吞噬细胞的入侵涉及到细胞骨架重构机制的颠覆，以产生富含肌动蛋白的细胞表面突起，旨在吞噬细菌。诱导这些富含肌动蛋白的结构的信号在一组多样化的细菌中具有相当大的重叠。这些结构内的分子组织协同作用以内化入侵的病原体。这个动态过程可以细分为三个阶段——肌动蛋白的募集、吞噬，最后是肌动蛋白的解体/内化。这篇综述将介绍目前对细菌入侵各个阶段所涉及的分子过程的认识，并提供一个视角，强调细菌入侵过程中肌动蛋白重构的时空控制。
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