Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Nat Rev Microbiol. 2011 Jul 18;9(9):635-46. doi: 10.1038/nrmicro2602.
Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.
细菌病原体在感染过程中与宿主膜相互作用，引发广泛的细胞过程。这些过程包括改变质膜和肌动蛋白细胞骨架之间的动态平衡，以及颠覆参与囊泡运输的膜相关途径。这些变化有助于病原体的进入和复制，并防止其被吞噬和降解。在这篇综述中，我们描述了许多细菌效应物对磷酸肌醇代谢、GTPase 信号和自噬的靶标对宿主膜的操纵。
