Storch W
Rheumaklinik Bad Driburg.
Immun Infekt. 1990 Feb;18(1):22-3.
25 serum samples of 22 patients with primary biliary cirrhosis (15 under or after treatment with D-penicillamine) were tested for antibodies against D-penicillamine. Complement-binding IgG-antibodies demonstrated by a 4 layer immunofluorescence test were found only in 3 patients with suggested D-penicillamine allergy. These findings suggest a causal relation between penicillamine antibodies and penicillamine-induced side effects.