抗胰岛素抗体对糖尿病控制的有害影响。

Deleterious effect of anti-insulin antibodies on diabetes control.

作者信息

Livneh A, Avraham H, Bistritzer T, Weisglass L, Theodor R, Sack J

机构信息

Department of Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

出版信息

Isr J Med Sci. 1990 Jan;26(1):11-5.

PMID:2179155

Abstract

We studied the effect of anti-insulin antibodies (AIA) on glycemia control in patients with insulin-dependent diabetes (IDD) by following the AIA titer changes with time. Although expected to remain constant, AIA levels were found to either increase or decrease in most patients. These AIA titer changes correlated significantly with changes in glycohemoglobin but not with changes in insulin dose. The results suggest that AIA may have a deleterious effect on glycemia control in IDD.

摘要

我们通过跟踪抗胰岛素抗体（AIA）滴度随时间的变化，研究了AIA对胰岛素依赖型糖尿病（IDD）患者血糖控制的影响。尽管预期AIA水平会保持恒定，但在大多数患者中发现其水平要么升高要么降低。这些AIA滴度变化与糖化血红蛋白的变化显著相关，但与胰岛素剂量的变化无关。结果表明，AIA可能对IDD患者的血糖控制产生有害影响。