Fink Ericka L, Beers Sue R, Russell Mary Louise, Bell Michael J
Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
J Pediatr Rehabil Med. 2009;2(4):309-19. doi: 10.3233/PRM-2009-0095.
Acquired brain injury from traumatic brain injury, cardiac arrest (CA), stroke, and central nervous system infection is a leading cause of morbidity and mortality in the pediatric population and reason for admission to inpatient rehabilitation. Therapeutic hypothermia is the only intervention shown to have efficacy from bench to bedside in improving neurological outcome after birth asphyxia and adult arrhythmia-induced CA, thought to be due to its multiple mechanisms of action. Research to determine if therapeutic hypothermia should be applied to other causes of brain injury and how to best apply it is underway in children and adults. Changes in clinical practice in the hospitalized brain-injured child may have effects on rehabilitation referral practices, goals and strategies of therapies offered, and may increase the degree of complex medical problems seen in children referred to inpatient rehabilitation.
创伤性脑损伤、心脏骤停（CA）、中风和中枢神经系统感染导致的获得性脑损伤是儿科人群发病和死亡的主要原因，也是住院康复治疗的入院原因。治疗性低温是唯一一种从实验室到临床均显示对改善出生窒息和成人心律失常性心脏骤停后的神经学结局有效的干预措施，其作用机制可能是多方面的。目前正在儿童和成人中开展研究，以确定治疗性低温是否应应用于其他脑损伤原因以及如何最佳应用。住院脑损伤儿童临床实践的变化可能会影响康复转诊实践、所提供治疗的目标和策略，并可能增加转诊至住院康复治疗的儿童中出现的复杂医疗问题的程度。
