Coombs R R
Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
J Antimicrob Chemother. 1990 Feb;25 Suppl B:53-60. doi: 10.1093/jac/25.suppl_b.53.
Over 25 years experience with fusidic acid in the treatment of bone and joint infections is reviewed. Fusidic acid, usually given concurrently with another antibiotic, has proved effective in a wide variety of staphylococcal infections, including acute osteomyelitis and septic arthritis. It is a valuable adjunct to surgery in patients with chronic osteomyelitis. Oral therapy is generally well tolerated, apart from gastrointestinal side effects in a small proportion of cases. Use of fusidic acid in other orthopaedic situations is considered in the light of recent information.
本文回顾了25年来夫西地酸在治疗骨与关节感染方面的经验。夫西地酸通常与另一种抗生素联合使用，已被证明对多种葡萄球菌感染有效，包括急性骨髓炎和化脓性关节炎。对于慢性骨髓炎患者，它是手术治疗的重要辅助药物。除了一小部分病例出现胃肠道副作用外，口服治疗一般耐受性良好。根据最新信息，还考虑了夫西地酸在其他骨科情况中的应用。
