Reproductive Medicine Associates of New York, New York, NY, USA.
J Assist Reprod Genet. 2011 Sep;28(10):911-5. doi: 10.1007/s10815-011-9614-9. Epub 2011 Jul 27.
To determine if patients with a low response to controlled ovarian hyperstimulation during IVF benefit from intracytoplasmic sperm injection (ICSI) METHODS: Retrospective analysis of 350 IVF cycles in which four or fewer oocytes were retrieved. Severe male factor cases were excluded from analysis. Conventional insemination (CI) and ICSI were compared, with primary outcome measures of fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, and pregnancy loss rate.
RESULT(S): Fertilization rates per oocyte retrieved for CI and ICSI were comparable (51.5% vs. 51.8%). Parallel implantation rates (22% vs. 25%), clinical pregnancy rates (32.8% vs. 33.3%), and loss rates (26.7% vs. 39.5%) were also noted. No difference in cancelled cycles was reported.
CONCLUSION(S): Our results demonstrate that in the presence of normal semen parameters, low egg number is not an indication to perform ICSI.
确定在体外受精（IVF）中对控制性卵巢过度刺激反应低的患者是否受益于卵胞浆内单精子注射（ICSI）。
对 350 个 IVF 周期进行回顾性分析，这些周期中仅取出了 4 个或更少的卵母细胞。严重的男性因素病例被排除在分析之外。比较了常规授精（CI）和 ICSI，主要的结局指标为受精率、着床率、每胚胎移植的临床妊娠率和流产率。
CI 和 ICSI 每枚卵母细胞的受精率相当（51.5% vs. 51.8%）。平行的着床率（22% vs. 25%）、临床妊娠率（32.8% vs. 33.3%）和流产率（26.7% vs. 39.5%）也被注意到。未报告取消周期的差异。
我们的结果表明，在正常精液参数的情况下，卵子数量少并不是进行 ICSI 的指征。
