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血浆中黄曲霉毒素 B1 白蛋白加合物和尿液中黄曲霉毒素 M1 与维生素 A 和 E 的血浆浓度有关。

Aflatoxin B1 albumin adducts in plasma and aflatoxin M1 in urine are associated with plasma concentrations of vitamins A and E.

机构信息

Department of Maternal and Child Health, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.

出版信息

Int J Vitam Nutr Res. 2010 Dec;80(6):355-68. doi: 10.1024/0300-9831/a000021.

Abstract

BACKGROUND

Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans.

OBJECTIVE

To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians.

METHODS

A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels.

RESULTS

Multivariable analysis showed that participants with high AF-ALB (>or=0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR)=2.61; CI=1.03-6.58; p=0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR=2.4; CI=0.96-6.05; p=0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR=0.31; CI=0.09-1.02; p=0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR=0.31; CI=0.10-0.97; p=0.04). Participants with high AF-ALB or high AFM1 (>or=437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR=5.88; CI=1.71-20.14; p=0.005) and (OR=5.84; CI=1.15-29.54; p=0.03) respectively.

CONCLUSIONS

These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.

摘要

背景

尽管黄曲霉毒素暴露与动物的微量营养素缺乏有关,但很少有研究调查黄曲霉毒素暴露对人类微量营养素代谢的影响。

目的

检测加纳人群血浆中黄曲霉毒素 B1(AFB1)白蛋白加合物(AF-ALB)与尿中黄曲霉 M1(AFM1)代谢物和血浆视黄醇(维生素 A)及α-生育酚(维生素 E)浓度之间的关系。

方法

对 147 名成年参与者进行了一项横断面研究。检测了血液和尿液样本中的黄曲霉毒素和维生素 A、E 水平。

结果

多变量分析显示,与低水平 AF-ALB(<0.80 pmol/mg 白蛋白)的参与者相比,高水平 AF-ALB(≥0.80 pmol/mg 白蛋白)的参与者维生素 A 缺乏的几率更高[比值比(OR)=2.61;95%置信区间(CI)=1.03-6.58;p=0.04]。高水平 AF-ALB 的参与者发生维生素 E 缺乏的几率也有所增加,但差异无统计学意义(OR=2.4;95%CI=0.96-6.05;p=0.06)。相反,AFM1 值较高的参与者维生素 A 缺乏的几率虽降低但差异无统计学意义(OR=0.31;95%CI=0.09-1.02;p=0.05),维生素 E 缺乏的几率显著降低(OR=0.31;95%CI=0.10-0.97;p=0.04)。高水平 AF-ALB 或高水平 AFM1(≥437.95 pg/dL 肌酐)的参与者乙型肝炎表面抗原(HBsAg)阳性的几率几乎增加了 6 倍(OR=5.88;95%CI=1.71-20.14;p=0.005)和(OR=5.84;95%CI=1.15-29.54;p=0.03)。

结论

这些数据表明黄曲霉毒素可能会改变血浆微量营养素状态。因此,预防黄曲霉毒素暴露可能会减少维生素 A 和 E 的缺乏。

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