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基于底物抑制的酶反应的生化计算生物催化异或门的实现和性质。

Realization and properties of biochemical-computing biocatalytic XOR gate based on enzyme inhibition by a substrate.

机构信息

Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13699, United States.

出版信息

J Phys Chem B. 2011 Aug 18;115(32):9838-45. doi: 10.1021/jp2041372. Epub 2011 Jul 28.

Abstract

We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in "biocomputing" systems utilizing biomolecules for information processing.

摘要

我们考虑了由一种酶催化的 XOR 逻辑门的实现,当输入的底物浓度足够大时,该酶会被其抑制。我们开发了一种模型来描述这种系统,这种方法适合于评估门的模拟噪声放大特性。我们对所获得的数据进行了拟合,以便在开发的模型中评估门的质量,并讨论了利用生物分子进行信息处理的“生物计算”系统中设计 XOR 门的一些方面。

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