Bernad Pineda Miguel, González Fernández Carlos Manuel, Fernández Prada Manuel, Fernández Campillo Jaime, Maeso Martín Rosaura, Garcés Puentes María Victoria
Reumatología, Hospital Universitario La Paz, Madrid, España.
Reumatol Clin. 2011 Jan-Feb;7(1):13-9. doi: 10.1016/j.reuma.2010.03.004. Epub 2010 Jun 26.
To know the characteristics of the postmenopausal women with osteoporosis consulting Rheumatology Hospital Divisions in Spain.
An epidemiologic, observational, transverse and multicentric study was performed from June to September 2008 in 63 rheumatology divisions in Spain. Six hundred and twenty nine osteoporotic postmenopausal women were studied using a questionnaire designed to get demographic, clinical, radiological, bone density, and functional information. Every physician had to choose only one patient per day, usually the first woman to come in and fulfill the inclusion and exclusion criteria.
Mean age of included women was 66,6 [9,2) years, weight:64,6[10,1] kg and body mass index: 26,1[4,1] kg/m(2). They were 3,1[2,8] cm shorter than the maximal historical height. 35,7% of them had a family history of fracture and 40,7% had a past history of fracture, of which 54,8% were vertebral fractures. Patients who received calcidiol <20 ng/ml sustained more falls (p=0,033) and fractures (p=0,006) than women receiving calcidiol >20 ng/ml. Risk of falls and fractures increased with advancing age and 51,5% of women who fell, had a fracture. 75% of women had poor calcium intake (≤400 mg/day). The Get up & go test showed a linear trend to an increased probability of >20s in relationship with the age as well as with an increased incidence of fractures. 71,8% of patients had back pain and in 85,3% it went from moderate to severe.
Most osteoporotic postmenopausal Spanish women have a low calcium intake, one out of three has a family history of fractures that increases fracture incidence and this shows a relationship with age and functional capacity; four out of ten have had any type of fractures, one out of three have fallen during the past year and half of these present back pain. Calcidiol levels have been evaluated in a small group of patients.
了解在西班牙各风湿病医院科室就诊的绝经后骨质疏松症女性的特征。
2008年6月至9月,在西班牙的63个风湿病科室开展了一项流行病学、观察性、横断面多中心研究。采用一份旨在获取人口统计学、临床、放射学、骨密度和功能信息的问卷,对629名绝经后骨质疏松症女性进行了研究。每位医生每天只能选择一名患者,通常是第一位前来就诊且符合纳入和排除标准的女性。
纳入研究的女性平均年龄为66.6(9.2)岁,体重为64.6(10.1)千克,体重指数为26.1(4.1)千克/平方米。她们比历史最高身高矮3.1(2.8)厘米。其中35.7%有骨折家族史,40.7%有既往骨折史,其中54.8%为椎体骨折。接受骨化二醇低于20纳克/毫升的患者比接受骨化二醇高于20纳克/毫升的女性跌倒(p = 0.033)和骨折(p = 0.006)的情况更多。跌倒和骨折的风险随着年龄的增长而增加,跌倒的女性中有51.5%发生了骨折。75%的女性钙摄入量低(≤400毫克/天)。从椅子上站起来行走测试显示,随着年龄的增长以及骨折发生率的增加,超过20秒的概率呈线性上升趋势。71.8%的患者有背痛,其中85.3%的背痛从中度到重度。
大多数西班牙绝经后骨质疏松症女性钙摄入量低,三分之一的人有骨折家族史,这会增加骨折发生率,且与年龄和功能能力有关;十分之四的人有过任何类型的骨折,三分之一的人在过去一年中跌倒过,其中一半有背痛。仅在一小部分患者中评估了骨化二醇水平。