血清白细胞介素（IL）-27 在缺血性心脏病患者中的水平。

Serum levels of interleukin (IL)-27 in patients with ischemic heart disease.

机构信息

Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

出版信息

Cytokine. 2011 Nov;56(2):153-6. doi: 10.1016/j.cyto.2011.06.014. Epub 2011 Jul 26.

DOI:10.1016/j.cyto.2011.06.014

PMID:21795063

Abstract

OBJECTIVE

Cytokines, the key mediators of immune responses, play an important role in the pathogenesis of cardiovascular diseases. The aim of this study was to evaluate the serum levels of IL-27 in patients with ischemic heart disease (IHD) and also to clarify its association with traditional risk factors of the disease.

METHODS

A total of 120 patients with IHD as having acute myocardial infarction (AMI; n=60) or unstable angina (UA; n=60) and 60 sex- and age-matched healthy subjects as a control group were enrolled in this cross-sectional, case-controlled study. Serum samples were collected from all participants (for AMI patients at 3-5 days after events and for UA at admission time) and tested for the levels of IL-27 by use of ELISA method.

RESULTS

The mean serum levels of IL-27 in AMI group (38.00±14.38 Pg/ml) and UA group (35.77±18.93 Pg/ml) were significantly higher than those observed in the control group (24.91±14.96 Pg/ml; P<0.0001 and 0.001, respectively). The mean serum levels of IL-27 in IHD patients with or without a certain traditional risk factor including hypertension, dyslipidemia, diabetes smoking were significantly higher as compared to those in the control group.

CONCLUSIONS

These results showed that the higher serum levels of IL-27 were associated with IHD. The presence or absence of certain traditional risk factors of IHD did not influence the serum levels of cytokine.

摘要

目的

细胞因子是免疫反应的关键介质，在心血管疾病的发病机制中发挥重要作用。本研究旨在评估缺血性心脏病（IHD）患者血清中 IL-27 的水平，并阐明其与疾病传统危险因素的关系。

方法

本研究为横断面病例对照研究，共纳入 120 例 IHD 患者，其中急性心肌梗死（AMI；n=60）或不稳定型心绞痛（UA；n=60），并选择 60 名性别和年龄匹配的健康受试者作为对照组。所有参与者均采集血清样本（AMI 患者于发病后 3-5 天，UA 患者于入院时），采用 ELISA 法检测 IL-27 水平。

结果

AMI 组（38.00±14.38 Pg/ml）和 UA 组（35.77±18.93 Pg/ml）的血清 IL-27 水平均显著高于对照组（24.91±14.96 Pg/ml；P<0.0001 和 0.001）。伴有或不伴有高血压、血脂异常、糖尿病、吸烟等特定传统危险因素的 IHD 患者的血清 IL-27 水平均显著高于对照组。