伊朗急性心肌梗死和不稳定型心绞痛患者感染负担之间的关联。

The association between infection burden in Iranian patients with acute myocardial infarction and unstable angina.

作者信息

Jafarzadeh Abdollah, Nemati M, Tahmasbi M, Ahmadi P, Rezayati M T, Sayadi A R

机构信息

Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

出版信息

Acta Med Indones. 2011 Apr;43(2):105-11.

PMID:21785173

Abstract

AIM

to evaluate the association of ischemic heart disease (IHD) with the number of pathogens (infection burden) among individuals with infection.

METHODS

a total of 120 patients with IHD as the acute myocardial infarction (AMI; n=60) or unstable angina (UA; n=60) group and 60 healthy subjects with sex- and age-matched as control group were enrolled in this study. Serum samples of all participants were tested for the presence of antibodies to Helicobacter pylori (H. pylori), cytomegalovirus (CMV), type-1 herpes simplex virus (HSV-1) and type- 2 HSV (HSV-2) by using ELISA.

RESULTS

Regarding the association of the infection burden with IHD, the prevalence ratios and 95% confidence intervals (CI) were 3.18 (CI: 1.50-6.72; P<0.001) for 3 seropositivities and 3.83 (CI: 0.84-17.43; P<0.05) for 4 seropositivities. The rate of subjects with high infection burden (3 seropositivities) was significantly higher in IHD group as compared to control group (53.4% vs 21.6%; P<0.01). Moreover, the mean number of seropositivities was also significantly higher in patients with IHD in comparison to control group (2.47 vs 1.68; P<0.01). The seroprevalence of anti-H. pylori antibodies in AMI and UA groups was significantly higher compared to control group (P<0.0001). The seroprevalence of anti-CMV antibodies in AMI and UA group was also significantly higher than those observed in control group (P<0.01). Moreover, the seroprevalence of anti-HSV-1 antibodies was significantly higher in AMI and UA groups in comparison to control group (P<0.001). The seroprevalence of anti-HSV-2 antibodies was similarly expressed in patients and healthy control group.

CONCLUSION

the infection burden was significantly higher in patients with IHD, which represent that the parameter should also be considered as an independent risk factor for development of IHD. The seroprevalence of H. pylori, CMV and HSV-1 were also higher in patients with IHD.

摘要

目的

评估感染个体中缺血性心脏病（IHD）与病原体数量（感染负担）之间的关联。

方法

本研究纳入了120例患有IHD的患者，分为急性心肌梗死（AMI；n = 60）组或不稳定型心绞痛（UA；n = 60）组，以及60名年龄和性别匹配的健康受试者作为对照组。使用酶联免疫吸附测定法（ELISA）检测所有参与者血清样本中幽门螺杆菌（H. pylori）、巨细胞病毒（CMV）、1型单纯疱疹病毒（HSV - 1）和2型HSV（HSV - 2）抗体的存在情况。

结果

关于感染负担与IHD的关联，3种血清学阳性的患病率比值及95%置信区间（CI）为3.18（CI：1.50 - 6.72；P < 0.001），4种血清学阳性的为3.83（CI：0.84 - 17.43；P < 0.05）。IHD组中高感染负担（3种血清学阳性）的受试者比例显著高于对照组（53.4%对21.6%；P < 0.01）。此外，IHD患者的血清学阳性平均数量也显著高于对照组（2.47对1.68；P < 0.01）。AMI组和UA组中抗H. pylori抗体的血清阳性率显著高于对照组（P < 0.0001）。AMI组和UA组中抗CMV抗体的血清阳性率也显著高于对照组（P < 0.01）。此外，AMI组和UA组中抗HSV - 1抗体的血清阳性率显著高于对照组（P < 0.001）。抗HSV - 2抗体的血清阳性率在患者和健康对照组中相似。