Cornea and Refractive Surgery Department, VISSUM Corporation, Alicante, Spain.
Br J Ophthalmol. 2011 Oct;95(10):1397-401. doi: 10.1136/bjophthalmol-2011-300170. Epub 2011 Jul 27.
To investigate the functional and cosmetic outcomes of keratopigmentation (KTP) in cases of moderate to severe visual dysfunctions owing to different iris disorders.
11 eyes with moderate to severe visual disabilities related to iris defects underwent KTP for functional and cosmetic restoration using micronised mineral pigments and assisted with modern technologies such as femtosecond laser and new automated keratopigmentation instruments for the intrastromal and superficial application of the pigments.
Following the KTP surgery, the visual-function-related symptoms improved in all cases, from significant improvement to total elimination. Eight patients were asymptomatic after the surgery. In two patients, minimal non-disabling symptoms remained after surgery. One patient with traumatic aniridia complained of significant residual glare at the 3-month postoperative visit and was reoperated to reduce the simulated pupil to 4 mm. The cosmetic outcomes were analysed and classified as excellent in eight patients and good in three.
KTP using new micronised mineral pigments and new surgical protocols has proven in this series to be an effective surgical technique for the management of moderate to severe visual dysfunctions related to iris defects.
研究因不同虹膜疾病导致中度至重度视力障碍的患者行角膜色素沉着术（KTP）的功能和美容效果。
11 只眼因虹膜缺损导致中度至重度视力障碍，采用微粉化矿物质颜料进行 KTP，辅助使用飞秒激光等现代技术，通过基质内和浅层应用颜料来实现功能和美容修复。
KTP 手术后，所有病例的视力相关症状均有改善，从显著改善到完全消除。8 例患者术后无症状。2 例患者术后仍存在轻微但不致残的症状。1 例创伤性无虹膜患者在术后 3 个月时抱怨仍有明显的残余眩光，随后再次手术将模拟瞳孔缩小至 4mm。对美容效果进行了分析和分类，8 例为优秀，3 例为良好。
在本系列研究中，使用新型微粉化矿物质颜料和新型手术方案的 KTP 已被证明是一种治疗与虹膜缺损相关的中度至重度视力障碍的有效手术技术。
