Ramalho L C de Barros, Gonçalves E M, de Carvalho W R G, Guerra-Junior G, Centeville M, Aoki F H, Morcillo A M, dos Santos Vilela M M, da Silva M T N
Center for Investigation in Pediatrics and Graduate Program in Child and Adolescent Health, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
Int J STD AIDS. 2011 Aug;22(8):453-6. doi: 10.1258/ijsa.2011.010516.
This cross-sectional study aimed to compare growth, nutritional status and body composition outcomes between a group of 94 HIV-infected children and adolescents on antiretroviral therapy (ART) and 364 healthy controls, and to evaluate their association with clinical and lifestyle variables within the HIV-infected group. When compared with the control group, HIV patients had higher risk of stunting (odds ratio [OR] 5.33, 95% confidence interval [CI]: 2.83-10.04) and thinness (OR 4.7, 95% CI: 2.44-9.06), higher waist-to-hip ratios (medians 0.89 versus 0.82 for boys and 0.90 versus 0.77 for girls, P < 0.001), and lower prevalence of overweight or obesity (OR 0.33, 95% CI: 0.14-0.78). Protease inhibitor usage was associated with thinness (OR 3.51, 95% CI 1.07-11.44) and lipoatrophy (OR 3.5, 95% CI 1.37-8.95). HIV-infected children on ART showed significant nutritional status and body composition abnormalities, consistent with the severity of vertical HIV infection and the consequences of prolonged ART.
这项横断面研究旨在比较94名接受抗逆转录病毒治疗（ART）的HIV感染儿童和青少年与364名健康对照者之间的生长、营养状况和身体成分结果，并评估它们与HIV感染组内临床和生活方式变量的关联。与对照组相比，HIV患者发育迟缓风险更高（优势比[OR] 5.33，95%置信区间[CI]：2.83 - 10.04），消瘦风险更高（OR 4.7，95% CI：2.44 - 9.06），腰臀比更高（男孩中位数为0.89对0.82，女孩中位数为0.90对0.77，P < 0.001），超重或肥胖患病率更低（OR 0.33，95% CI：0.14 - 0.78）。使用蛋白酶抑制剂与消瘦（OR 3.51，95% CI 1.07 - 11.44）和脂肪萎缩（OR 3.5，95% CI 1.37 - 8.95）有关。接受ART的HIV感染儿童表现出明显的营养状况和身体成分异常，这与垂直HIV感染的严重程度以及长期ART的后果一致。
