Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Am J Clin Nutr. 2011 Sep;94(3):767-74. doi: 10.3945/ajcn.110.004895. Epub 2011 Jul 27.
Despite the well-known recidivism of obesity, surprisingly little is known about the composition of body weight during weight regain.
The objective of this study was to determine whether the composition of body weight regained after intentional weight loss is similar to the composition of body weight lost.
The design was a follow-up to a randomized controlled trial of weight loss in which body composition was analyzed and compared in 78 postmenopausal women before the intervention, immediately after the intervention, and 6 and 12 mo after the intervention.
All body mass and composition variables were lower immediately after weight loss than at baseline (all P < 0.05). More fat than lean mass was lost with weight loss, which resulted in body-composition changes favoring a lower percentage of body fat and a higher lean-to-fat mass ratio (P < 0.001). Considerable interindividual variability in weight regain was noted (CV = 1.07). In women who regained ≥2 kg body weight, a decreasing trend in the lean-to-fat mass ratio was observed, which indicated greater fat mass accretion than lean mass accretion (P < 0.001). Specifically, for every 1 kg fat lost during the weight-loss intervention, 0.26 kg lean tissue was lost; for every 1 kg fat regained over the following year, only 0.12 kg lean tissue was regained.
Although not all postmenopausal women who intentionally lose weight will regain it within 1 y, the data suggest that fat mass is regained to a greater degree than is lean mass in those who do experience some weight regain. The health ramifications of our findings remain to be seen.
尽管肥胖的复发率众所周知，但人们对体重恢复过程中体重的构成知之甚少。
本研究旨在确定在有意减肥后体重恢复时的体重构成是否与减轻的体重构成相似。
该设计是减肥的一项随机对照试验的随访，在该试验中，对 78 名绝经后妇女进行了身体成分分析和比较，这些妇女在干预前、干预后立即以及干预后 6 个月和 12 个月时进行了分析和比较。
所有体重和成分变量在减肥后立即均低于基线（均 P < 0.05）。与减肥相比，丢失的脂肪多于瘦体重，这导致身体成分发生变化，有利于降低体脂百分比和提高瘦体重与脂肪质量比（P < 0.001）。体重恢复的个体间差异较大（CV = 1.07）。在体重增加≥2 kg 的妇女中，观察到瘦体重与脂肪质量比呈下降趋势，这表明脂肪质量的增加大于瘦体重的增加（P < 0.001）。具体而言，在减肥干预期间每丢失 1 kg 脂肪，就会丢失 0.26 kg 的瘦组织；在接下来的 1 年中每增加 1 kg 脂肪，仅恢复 0.12 kg 的瘦组织。
尽管并非所有有意减肥的绝经后妇女在 1 年内都会恢复体重，但数据表明，在确实出现体重恢复的妇女中，脂肪质量的恢复程度大于瘦体重。我们研究结果的健康影响还有待观察。
