Jebb S A, Siervo M, Murgatroyd P R, Evans S, Frühbeck G, Prentice A M
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn, Cambridge, UK.
Int J Obes (Lond). 2007 May;31(5):756-62. doi: 10.1038/sj.ijo.0803475. Epub 2006 Oct 24.
To investigate changes in body composition and the validity of the leg-to-leg bioimpedance (LTL) method to measure body fat during active weight loss (WL) and weight regain (WR).
Longitudinal, 12-week weight loss intervention (3.3-3.8 MJ/day) and subsequent follow-up at 1 year.
Fifty-eight adult women aged between 24 and 65 years (mean age: 46.8+/-8.9 years) and with a body mass index (BMI) > or =25 kg/m(2) (mean BMI: 31.6+/-2.5 kg/m(2), range=26.0-48.2 kg/m(2)) participated in the study.
Fat mass (FM) was measured at baseline, 12 weeks, 24 weeks and 52 weeks using three- and four-compartment (4-C) models, air displacement plethysmography (ADP), deuterium dilution - total body water (TBW), dual-energy X-ray absorptiometry (DXA), skinfold thickness (SFT), tetrapolar bioelectrical impedance analysis (T-BIA) and LTL.
At the end of the weight loss programme, subjects lost 9.9+/-3.5 kg weight (P<0.001) and 7.6+/-0.5 kg fat (P<0.001) but after 1 year they had regained 4.9+/-3.7 kg of weight and 3.7+/-2.9 kg of fat. The 4-C model showed that FM and TBW accounted for 76.2 and 23.6% of the loss in body mass and 81.8 and 17.7% of the tissue accrued during weight regain, respectively. The estimate of body fat change by LTL relative to multi-compartment models (WL(bias+/-2s.d.)=0.51+/-3.26 kg; WR(bias+/-2s.d.)=-0.25+/-2.30 kg) was similar to ADP, DXA and TBW in both phases but it was better than T-BIA (WL(bias+/-2s.d.)=0.17+/-7.90 kg; WR(bias+/-2s.d.)=-0.29+/-7.59 kg) and skinfold thickness (WL(bias+/-2s.d.)=2.68+/-6.68 kg; WR(bias+/-2s.d.)=-0.84+/-3.80 kg).
Weight loss and regain were associated with minimal changes in lean tissue as measured using multi-compartment models. The LTL system is a useful method to measure body composition changes during clinical weight management programmes.
研究主动减重（WL）和体重恢复（WR）期间身体成分的变化以及腿对腿生物电阻抗（LTL）法测量体脂的有效性。
纵向研究，为期12周的减重干预（3.3 - 3.8兆焦耳/天）及随后1年的随访。
58名年龄在24至65岁之间（平均年龄：46.8±8.9岁）、体重指数（BMI）≥25千克/米²（平均BMI：31.6±2.5千克/米²，范围 = 26.0 - 48.2千克/米²）的成年女性参与了该研究。
在基线、第12周、第24周和第52周使用三室和四室（4 - C）模型、空气置换体积描记法（ADP）、氘稀释 - 总体水（TBW）、双能X线吸收法（DXA）、皮褶厚度（SFT）、四极生物电阻抗分析（T - BIA）和LTL测量脂肪量（FM）。
在减重计划结束时，受试者体重减轻了9.9±3.5千克（P<0.001），脂肪减少了7.6±0.5千克（P<0.001），但1年后她们体重恢复了4.9±3.7千克，脂肪恢复了3.7±2.9千克。4 - C模型显示，FM和TBW分别占体重减轻量的76.2%和23.6%，以及体重恢复期间增加组织量的81.8%和17.7%。在两个阶段中，相对于多室模型，LTL对体脂变化的估计（WL（偏差±2标准差）=0.51±3.26千克；WR（偏差±2标准差）=-0.25±2.30千克）与ADP、DXA和TBW相似，但优于T - BIA（WL（偏差±2标准差）=0.17±7.90千克；WR（偏差±2标准差）=-0.29±7.59千克）和皮褶厚度（WL（偏差±2标准差）=2.68±6.68千克；WR（偏差±2标准差）=-0.84±3.80千克）。
使用多室模型测量发现，体重减轻和恢复与瘦组织的最小变化相关。LTL系统是临床体重管理计划中测量身体成分变化的一种有用方法。
