Takahashi M, Ushijima T, Seto A
Department of Microbiology, Shiga University of Medical Science, Japan.
J Med Microbiol. 1990 Mar;31(3):191-4. doi: 10.1099/00222615-31-3-191.
A/J and BALB/c mice differ genetically in their resistance to the facultative intracellular bacterium Salmonella typhimurium. We compared the responses of these strains of mice to a virulent S. typhimurium infection. BALB/c mice mobilised more peritoneal exudate cells in response to the infection than did A/J mice 30 h after infection, but the increase in bacterial counts in the livers and spleens of BALB/c mice was 10-fold higher than in A/J mice. The response to Concanavalin A (Con A) of spleen cells from BALB/c mice was depressed, and both L3T4+ and Lyt-2+ T cell subpopulations were decreased following the infection, whereas the response to Con A of A/J mice was increased and the T cell subpopulations were not altered significantly. These results suggest that A/J mice respond more actively to S. typhimurium infection than do BALB/c mice, and this may be related to the natural resistance of mice.
A/J小鼠和BALB/c小鼠在对兼性胞内菌鼠伤寒沙门氏菌的抵抗力方面存在基因差异。我们比较了这两种品系小鼠对强毒力鼠伤寒沙门氏菌感染的反应。感染后30小时，BALB/c小鼠对感染的反应比A/J小鼠调动了更多的腹腔渗出细胞，但BALB/c小鼠肝脏和脾脏中的细菌计数增加量比A/J小鼠高10倍。BALB/c小鼠脾细胞对刀豆球蛋白A（Con A）的反应受到抑制，感染后L3T4 +和Lyt-2 + T细胞亚群均减少，而A/J小鼠对Con A的反应增强，T细胞亚群没有明显改变。这些结果表明，A/J小鼠对鼠伤寒沙门氏菌感染的反应比BALB/c小鼠更活跃，这可能与小鼠的天然抵抗力有关。
