Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
J Perinatol. 2011 Aug;31(8):567-70. doi: 10.1038/jp.2011.4.
Permanent neonatal diabetes was previously assumed to require insulin injection or infusion for life. Recently, permanent neonatal diabetes resulting from mutations in the two protein subunits of the adenosine triphosphate-sensitive potassium channel (Kir6.2 and SUR1) has proven to be successfully treatable with high doses of sulfonylureas rather than insulin. Many patients with these mutations first develop hyperglycemia in the nursery or intensive care unit. The awareness of the neonatolgist of this entity can have dramatic effects on the long-term care and quality of life of these patients and their families. In this study, we present the experience of our center, highlighting aspects relevant to neonatal diagnosis and treatment.
先前认为，永久性新生儿糖尿病需要终生注射或输注胰岛素。最近，研究发现由三磷酸腺苷敏感性钾通道（Kir6.2 和 SUR1）两个蛋白亚单位突变引起的永久性新生儿糖尿病可以通过大剂量磺脲类药物治疗而不是胰岛素治疗。许多患有这些突变的患者首先在新生儿病房或重症监护病房出现高血糖。新生儿科医生对这种疾病的认识会对这些患者及其家庭的长期护理和生活质量产生重大影响。在这项研究中，我们介绍了我们中心的经验，重点介绍了与新生儿诊断和治疗相关的方面。
