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在一名完全性肺静脉异位连接修复术后出现复发性肺静脉梗阻的婴儿中，使用依维莫司洗脱支架植入术和紫杉醇球囊血管成形术后的血清水平。

Serum levels after everolimus-stent implantation and paclitaxel-balloon angioplasty in an infant with recurrent pulmonary vein obstruction after repaired total anomalous pulmonary venous connection.

作者信息

Müller Matthias J, Krause Ulrich, Paul Thomas, Schneider Heike E

机构信息

Department for Pediatric Cardiology and Intensive Care Medicine, Georg-August-University Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany.

出版信息

Pediatr Cardiol. 2011 Oct;32(7):1036-9. doi: 10.1007/s00246-011-0054-1. Epub 2011 Jul 28.

DOI:10.1007/s00246-011-0054-1
PMID:21796444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3174384/
Abstract

Everolimus-eluting stents and paclitaxel-coated balloons are used in the interventional treatment of coronary artery disease in adults to reduce the restenosis rate and in small-vessel disease. Both substances are released into the circulation. We report systemic drug exposure after implantation of one everolimus-eluting stent and dilation with one paclitaxel-coated balloon in an 8-month-old infant, which was used as an innovative therapy for recurrent pulmonary vein stenosis.

摘要

依维莫司洗脱支架和紫杉醇涂层球囊用于成人冠状动脉疾病的介入治疗，以降低再狭窄率，也用于小血管疾病治疗。两种物质都会释放到循环系统中。我们报告了一名8个月大婴儿植入一枚依维莫司洗脱支架并用一枚紫杉醇涂层球囊扩张后出现的全身药物暴露情况，该治疗被用作复发性肺静脉狭窄的创新疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7541/3174384/83dcaea53838/246_2011_54_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7541/3174384/73533d57d3a6/246_2011_54_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7541/3174384/83dcaea53838/246_2011_54_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7541/3174384/73533d57d3a6/246_2011_54_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7541/3174384/83dcaea53838/246_2011_54_Fig2_HTML.jpg

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本文引用的文献

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Total anomalous pulmonary venous connection: morphology and outcome from an international population-based study.完全性肺静脉异位连接：一项国际基于人群的研究中的形态学和结局。
Circulation. 2010 Dec 21;122(25):2718-26. doi: 10.1161/CIRCULATIONAHA.110.940825. Epub 2010 Dec 6.
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Everolimus: a proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology.依维莫司：一种增殖信号抑制剂，在器官移植、肿瘤学和心脏病学中有临床应用。
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First experience with a new drug-eluting balloon for the treatment of congenital pulmonary vein stenosis in a neonate.
首次使用新型药物洗脱球囊治疗新生儿先天性肺静脉狭窄的经验。
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Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours.紫杉醇与口服雷帕霉素靶蛋白（mTOR）抑制剂依维莫司在晚期实体瘤中的安全性及药代动力学
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