Abdel-Hamid Hala F, Soliman Abdelmohsen, Helaly Fahima M, Ragab Shadia
Chemistry of Pesticides Dept., National Research Center, Dokki, Giza, Egypt.
Acta Pol Pharm. 2011 Jul-Aug;68(4):499-505.
On the basis of monitoring the inhibition of the growth of human cancer cells, a series of novel furan derivatives of possessing a broader spectrum of antitumor activity and fewer toxic side effects than traditional anticancer drugs have been studied. Ten selected furan derivatives were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line. Moreover, the biochemical effects of the selected furan derivatives on some enzymes such as aspartate and a lanine aminotransferases (ASTand ALT) and alkaline phosphatase (ALP), in addition to albumin, globulins, creatinine, total lipids, cholesterol, triglycerides and bilirubin in serum of mice were studied in comparison to 5-fluorouracil and doxorubicin. The antitumor activity results indicated that the selected furan derivatives showed growth of inhibition activity against the tested cell line but with varying intensities extents. Results of the biochemical investigations indicated that 5-fluorouracil and doxorubicin caused significant changes in the level of all parameters tested while treatment with the selected compounds showed slight, moderate or no significant changes.
基于对人癌细胞生长抑制的监测，研究了一系列新型呋喃衍生物，它们具有比传统抗癌药物更广泛的抗肿瘤活性且毒副作用更少。十种选定的呋喃衍生物被用于一个筛选系统，以研究它们对肝癌（HEPG2）细胞系的抗肿瘤效力。此外，与5-氟尿嘧啶和阿霉素相比，研究了选定的呋喃衍生物对小鼠血清中某些酶（如天冬氨酸和丙氨酸转氨酶（AST和ALT）以及碱性磷酸酶（ALP））的生化作用，以及对白蛋白、球蛋白、肌酐、总脂质、胆固醇、甘油三酯和胆红素的影响。抗肿瘤活性结果表明，选定的呋喃衍生物对受试细胞系显示出生长抑制活性，但强度程度不同。生化研究结果表明，5-氟尿嘧啶和阿霉素导致所有测试参数水平发生显著变化，而用选定化合物处理则显示出轻微、中等或无显著变化。
