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[来自木霉的抗菌肽短肽菌素——综述]

[Antimicrobial peptides peptaibols from trichoderma--a review].

作者信息

Song Xiaoyan, Zhang Yuzhong, Wang Yuanxiu

机构信息

College of Medical and Life Science, University of Jinan, Jinan 250022, China.

出版信息

Wei Sheng Wu Xue Bao. 2011 Apr;51(4):438-44.

Abstract

Peptaibols are a family of antimicrobial peptides, which are synthesized by non-ribosomal peptide synthetases (NRPS) and contain high proportions of alpha-aminoisobytyric acid (Aib). Up to now, 317 peptaibols have been identified, and the majority of them are produced by Trichoderma strains. In this review, we described the diversity, fermation, purification, identification and biosynthesis of peptaibols from Trichoderma.

摘要

短杆菌肽是一类抗菌肽,由非核糖体肽合成酶(NRPS)合成,含有高比例的α-氨基异丁酸(Aib)。截至目前,已鉴定出317种短杆菌肽,其中大部分由木霉菌株产生。在本综述中,我们描述了来自木霉的短杆菌肽的多样性、发酵、纯化、鉴定和生物合成。

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