Song Xiaoyan, Zhang Yuzhong, Wang Yuanxiu
College of Medical and Life Science, University of Jinan, Jinan 250022, China.
Wei Sheng Wu Xue Bao. 2011 Apr;51(4):438-44.
Peptaibols are a family of antimicrobial peptides, which are synthesized by non-ribosomal peptide synthetases (NRPS) and contain high proportions of alpha-aminoisobytyric acid (Aib). Up to now, 317 peptaibols have been identified, and the majority of them are produced by Trichoderma strains. In this review, we described the diversity, fermation, purification, identification and biosynthesis of peptaibols from Trichoderma.
短杆菌肽是一类抗菌肽,由非核糖体肽合成酶(NRPS)合成,含有高比例的α-氨基异丁酸(Aib)。截至目前,已鉴定出317种短杆菌肽,其中大部分由木霉菌株产生。在本综述中,我们描述了来自木霉的短杆菌肽的多样性、发酵、纯化、鉴定和生物合成。