Mardegan M C, Ramos M C, Adad S J, Michelin M A, Shimba D, Murta E F C
Gynecology and Obstetrics, UFTM, Uberaba, Minas Gerais, Brazil.
Eur J Gynaecol Oncol. 2011;32(3):297-302.
Conservative treatment with intralesional interferon (IFN) is a therapeutic option for cervical intraepithelial neoplasia (CIN) patients of childbearing age.
The study group was made up of patients diagnosed with a high-grade lesion and treated with intralesional human recombinant IFNalpha-2b. Vaginal secretion was collected during IFNalpha-2b treatment for analysis of cytokines and viral load.
The initial histology diagnostic was 62.5% (n = 5) with CIN 2 and 37.5% (n = 3) with CIN 3. In terms of clinical evaluation and anatomopathology, 6.5% (n = 5) had a good clinical response, while 37.5% (n = 3) had therapeutic failure. All the patients with therapeutic failure were smokers. Interleukin 6 and tumor necrosis factor-alpha concentrations were raised at the sixth application for the patient group who failed to respond to therapy compared to the responsive group (p = 0.0357). Patients with a good response exhibited a reduction in human papillomavirus viral load (p = 0.03).
Patients that had a good response had lower concentrations of inflammatory cytokines than did non-responders.
病灶内注射干扰素（IFN）进行保守治疗是育龄期宫颈上皮内瘤变（CIN）患者的一种治疗选择。
研究组由被诊断为高级别病变并接受病灶内注射人重组IFNα-2b治疗的患者组成。在IFNα-2b治疗期间收集阴道分泌物，用于分析细胞因子和病毒载量。
初始组织学诊断为CIN 2的患者占62.5%（n = 5），CIN 3的患者占37.5%（n = 3）。在临床评估和解剖病理学方面，6.5%（n = 5）有良好的临床反应，而37.5%（n = 3）治疗失败。所有治疗失败的患者均为吸烟者。与有反应的组相比，治疗无反应的患者组在第六次用药时白细胞介素6和肿瘤坏死因子-α浓度升高（p = 0.0357）。有良好反应的患者人乳头瘤病毒病毒载量降低（p = 0.03）。
有良好反应的患者炎症细胞因子浓度低于无反应者。
