a Bascom Palmer Eye Institute, Department of Ophthalmology , University of Miami , Miami , Florida , USA.
b Miami Veterans Administration Medical Center , Miami , Florida , USA.
Ocul Immunol Inflamm. 2019;27(2):288-293. doi: 10.1080/09273948.2017.1394470. Epub 2017 Nov 30.
Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN.
Retrospective case series.
Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis. All patients had treatment complicated by multiple surgeries, recurrences, or advanced disease. The patients initially received medical treatment with topical interferon-alpha-2b (IFNα2b). However, all the patients had recurrences and required modification of treatment including topical 5-fluorouracil (5-FU).
We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and long-term treatment.
很少有研究描述了眼表面鳞状上皮瘤（OSSN）及其与特应性疾病的关系，并且对于特应性患者的 OSSN 病程也没有共识。因此，我们报告了三例特应性和 OSSN 患者。
回顾性病例系列研究。
3 名男性患者的平均年龄为 73 岁，患有 OSSN 和特应性病史，接受了免疫抑制治疗。他们的病史包括特应性皮炎和角结膜炎。所有患者的治疗均因多次手术、复发或疾病进展而复杂化。患者最初接受了局部干扰素-α-2b（IFNα2b）治疗。然而，所有患者均复发，需要修改治疗方案，包括局部 5-氟尿嘧啶（5-FU）。
我们报告了三例有特应性病史的患者，他们的 OSSN 表现和病程具有挑战性。总体而言，我们的病例对局部 5-氟尿嘧啶的反应优于局部干扰素-α-2b，但复发很常见。这些患者可能受益于更积极和长期的治疗。
