Beijing National Laboratory for Molecular Science (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
Org Lett. 2011 Aug 19;13(16):4414-7. doi: 10.1021/ol201749c. Epub 2011 Jul 28.
Total synthesis of the proposed structure of (-)-hyacinthacine C(5) and its epimers at C6 and C7 is described. A key step of the synthesis was the construction of the bicyclic pyrrolizidine system by means of a nucleophilic addition of a dithiane to a cyclic nitrone followed by a Cope-House cyclization.
（-）-百春花 C（5）及其 C6 和 C7 差向异构体的提议结构的全合成描述如下。合成的关键步骤是通过二硫杂环戊烷对环状硝酮的亲核加成，然后进行 Cope-House 环化，构建双环吡咯里西啶系统。
