细胞表面具有分形特征：正常和癌变的宫颈细胞在纳米尺度下表现出不同的表面黏附图谱分形行为。
Cell surface as a fractal: normal and cancerous cervical cells demonstrate different fractal behavior of surface adhesion maps at the nanoscale.
机构信息
Department of Physics, Clarkson University, Potsdam, New York 13699-5820, USA.
出版信息
Phys Rev Lett. 2011 Jul 8;107(2):028101. doi: 10.1103/PhysRevLett.107.028101.
Abstract
Here we show that the surface of human cervical epithelial cells demonstrates substantially different fractal behavior when the cell becomes cancerous. Analyzing the adhesion maps of individual cervical cells, which were obtained using the atomic force microscopy operating in the HarmoniX mode, we found that cancerous cells demonstrate simple fractal behavior, whereas normal cells can only be approximated at best as multifractal. Tested on ~300 cells collected from 12 humans, the fractal dimensionality of cancerous cells is found to be unambiguously higher than that for normal cells.
摘要
在这里，我们展示了当人类宫颈上皮细胞癌变时，其表面表现出显著不同的分形行为。通过分析使用 HarmoniX 模式操作的原子力显微镜获得的单个宫颈细胞的粘附图谱，我们发现癌变细胞表现出简单的分形行为，而正常细胞最多只能近似为多分形。在从 12 个人体中收集的约 300 个细胞上进行测试，发现癌变细胞的分形维数明显高于正常细胞。
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