National Institute of Science and Technology Translational Medicine-INCT-TM (CNPq), Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Alberto Rocha, 200, Vila Dagmar, Belford Roxo, Rio de Janeiro, 26130-170, Brazil.
Expert Rev Neurother. 2011 Aug;11(8):1185-95. doi: 10.1586/ern.11.83.
This systematic review aimed to examine the results of studies that have investigated the induction of panic attacks and/or the anxiogenic effect of the caffeine challenge test in patients with panic disorder. The literature search was performed in PubMed, Biblioteca Virtual em Saúde and the ISI Web of Knowledge. The words used for the search were caffeine, caffeine challenge test, panic disorder, panic attacks and anxiety disorder. In total, we selected eight randomized, double-blind studies where caffeine was administered orally, and none of them controlled for confounding factors in the analysis. The percentage of loss during follow-up ranged between 14.3% and 73.1%. The eight studies all showed a positive association between caffeine and anxiogenic effects and/or panic disorder.
本系统评价旨在考察研究咖啡因激发试验引起惊恐发作和/或焦虑效应在惊恐障碍患者中的结果。文献检索在 PubMed、Virtual Biblioteca em Saúde 和 ISI Web of Knowledge 中进行。检索使用的词为咖啡因、咖啡因激发试验、惊恐障碍、惊恐发作和焦虑障碍。共选择了 8 项随机、双盲研究，其中咖啡因经口服给予，且分析中均未对混杂因素进行控制。随访期间的失访率在 14.3%至 73.1%之间。这 8 项研究均显示咖啡因与焦虑效应和/或惊恐障碍之间存在正相关关系。
