Department of Pediatric Infectious Diseases, University of Washington & Seattle Children's Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101-1304, USA.
Future Microbiol. 2011 Jul;6(7):747-61. doi: 10.2217/fmb.11.62.
Living organisms adapt to the dynamic external environment for their survival. Environmental adaptation in prokaryotes is thought to be primarily accomplished by signaling events mediated by two-component systems, consisting of histidine kinases and response regulators. However, eukaryotic-like serine/threonine kinases (STKs) have recently been described to regulate growth, antibiotic resistance and virulence of pathogenic bacteria. This article summarizes the role of STKs and their cognate phosphatases (STPs) in Gram-positive cocci that cause invasive infections in humans. Given that a large number of inhibitors to eukaryotic STKs are approved for use in humans, understanding how serine/threonine phosphorylation regulates virulence and antibiotic resistance will be beneficial for the development of novel therapeutic strategies against bacterial infections.
生物为了生存而适应动态的外部环境。原核生物的环境适应被认为主要是通过由组氨酸激酶和反应调节剂组成的双组分系统介导的信号事件来完成的。然而，最近已经描述了真核样丝氨酸/苏氨酸激酶（STKs）调节引起人类侵袭性感染的致病性细菌的生长、抗生素耐药性和毒力。本文总结了 STKs 及其同源磷酸酶（STPs）在引起人类侵袭性感染的革兰阳性球菌中的作用。鉴于大量用于人类的真核 STKs 抑制剂已获得批准，了解丝氨酸/苏氨酸磷酸化如何调节毒力和抗生素耐药性将有助于开发针对细菌感染的新型治疗策略。
