Ogbera Okeoghene Anthonia, Azenabor Alfred
Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
J Coll Physicians Surg Pak. 2011 Aug;21(8):455-9.
To determine the frequency of hyperfibrinogenaemia, elevated C-reactive protein, hyperuricaemia and elevated lipoprotein A in a clinic population of patients with type 2 Diabetes mellitus (DM) compared with healthy controls; and determine the interrelationship between fasting plasma glucose levels and indices of long-term glycaemic control (fructosamine and glycosylated haemoglobin) in DM.
Cross-sectional, analytical study.
The study was conducted at the Lagos State University Teaching Hospital, Ikeja, from April to June 2009.
A total of 200 patients with type 2 DM and 100 age and gender matched healthy controls were recruited for the study. Glycaemic control was assessed using fasting blood glucose, fructosamine and glycosylated haemoglobin levels. The non-traditional risk factors studied included C-reactive protein (CRP), Lipoprotein a (Lpa), serum uric acid (SUA), microalbuminuria and fibrinogen. Mann-whitney, chi-square and Pearson's correlation tests were used for analysis as applicable.
Hyperfibrinoginaemia, elevated CRP, LPa, microalbuminuria and hyperuricaemia were present in 3.5%, 65%, 12%, 6% and 57% respectively in type 2 DM. The mean levels of these CV risk factors were significantly higher in subjects with type 2 DM than that of the control subject. There was a positive and significant correlation between HbA1c and FBS (r=0.46, p=0.0001) and HbA1c and fructosamine (r=0.49, p=0.0001). All studied CVS risk factors were related to indices of glycaemic control which were found to be interrelated. Fasting blood glucose significantly correlated with both HbA1c and fructosamine but HbA1c showed better correlation to FPG than fructosamine (r=0.51 vs. 0.32).
Glycosylated haemoglobin and fasting plasma glucose but not fructosamine are significantly associated with microalbuminuria, fibrinogen SUA and CRP in type 2 DM. HbA1c was found to be better than fructosamine in monitoring overall long-term glycaemic control.
与健康对照相比，确定2型糖尿病（DM）门诊患者中高纤维蛋白原血症、C反应蛋白升高、高尿酸血症和脂蛋白A升高的发生率；并确定DM患者空腹血糖水平与长期血糖控制指标（果糖胺和糖化血红蛋白）之间的相互关系。
横断面分析研究。
该研究于2009年4月至6月在拉各斯州立大学教学医院伊凯贾进行。
共招募200例2型DM患者和100例年龄及性别匹配的健康对照进行研究。使用空腹血糖、果糖胺和糖化血红蛋白水平评估血糖控制情况。研究的非传统危险因素包括C反应蛋白（CRP）、脂蛋白a（Lpa）、血清尿酸（SUA）、微量白蛋白尿和纤维蛋白原。根据适用情况，使用曼-惠特尼检验、卡方检验和皮尔逊相关检验进行分析。
2型DM患者中高纤维蛋白原血症、CRP升高、LPa升高、微量白蛋白尿和高尿酸血症的发生率分别为3.5%、65%、12%、6%和57%。这些心血管危险因素的平均水平在2型DM患者中显著高于对照受试者。糖化血红蛋白与空腹血糖（r=0.46，p=0.0001）以及糖化血红蛋白与果糖胺（r=0.49，p=0.0001）之间存在显著正相关。所有研究的心血管危险因素均与血糖控制指标相关，且这些指标相互关联。空腹血糖与糖化血红蛋白和果糖胺均显著相关，但糖化血红蛋白与空腹血糖的相关性优于果糖胺（r=0.51对0.32）。
在2型DM中，糖化血红蛋白和空腹血糖而非果糖胺与微量白蛋白尿、纤维蛋白原、SUA和CRP显著相关。发现糖化血红蛋白在监测总体长期血糖控制方面优于果糖胺。
