Department of Microbiology, The University of Hong Kong, Hong Kong, China.
Antiviral Res. 2011 Sep;91(3):330-4. doi: 10.1016/j.antiviral.2011.07.011. Epub 2011 Jul 21.
A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.
先前的研究表明，选择性环氧化酶-2（COX-2）抑制剂可抑制 H5N1 感染的原代人细胞中过度诱导的促炎反应。在这里，我们证明 COX-2 抑制剂可抑制人巨噬细胞中的 H5N1 病毒复制，这表明 H5N1 病毒复制（比季节性 H1N1 病毒更甚）依赖于宿主细胞中 COX-2 依赖性信号通路的激活。COX-2 及其下游信号通路值得作为治疗 H5N1 疾病的新治疗靶点进行详细研究。
