Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bone. 2012 Feb;50(2):518-24. doi: 10.1016/j.bone.2011.07.015. Epub 2011 Jul 23.
Apolipoprotein E (apoE) is a major structural apolipoprotein of several lipoprotein classes. Over the last 13 years, numerous studies have focused on the question whether human apoE affects bone phenotypes and, more recently, whether apoE regulates bone metabolism in mice. Here, we first provide a brief background introduction into the structure, established physiological and pathophysiological functions of apoE, and will then discuss the new aspects of the emerging role of apoE in bone.
载脂蛋白 E(apoE)是几种脂蛋白类别的主要结构载脂蛋白。在过去的 13 年中,许多研究都集中在人类 apoE 是否影响骨表型以及最近 apoE 是否调节小鼠骨代谢的问题上。在这里,我们首先简要介绍 apoE 的结构、已确立的生理和病理生理学功能,然后讨论 apoE 在骨中新兴作用的新方面。